Protein Intake and Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis.

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2021-06-04 eCollection Date: 2021-01-01 DOI:10.1177/11786388211022373
Hélio José Coelho-Júnior, Riccardo Calvani, Francesco Landi, Anna Picca, Emanuele Marzetti
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引用次数: 6

Abstract

Introduction: The present study investigated the association between protein intake and cognitive function in older adults.

Methods: We performed a literature search with no restriction on publication year in MEDLINE, SCOPUS, CINAHL, AgeLine from inception up to October 2020. Observational studies that investigated as a primary or secondary outcome the association of protein intake and cognitive function in older adults aged ⩾60 years were included.

Results: Nine cross-sectional studies that investigated a total of 4929 older adults were included in the qualitative analysis. Overall cognitive function was examined in 6 studies. Four investigations reported null associations and 2 studies found that older adults with a high protein intake had higher global cognitive function than their counterparts. Results from the meta-analysis suggested that there were no significant associations between protein consumption and global cognitive function in older adults, regardless of gender. Three studies investigated other cognitive domains. Memory and protein intake were significantly and positively correlated in all studies. In addition, visuospatial, verbal fluency, processing speed, and sustained attention were positively associated with protein consumption in 1 study each.

Conclusion: No significant associations between protein intake and global cognitive function were observed in neither qualitative nor quantitative analyses. The association between protein consumption with multiple other cognitive domains were also tested. As a whole, 3 studies reported a positive and significant association between high protein intake and memory, while 1 study observed a significant and positive association with visuospatial, verbal fluency, processing speed, and sustained attention.

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老年人蛋白质摄入与认知功能:系统回顾和荟萃分析。
本研究调查了老年人蛋白质摄入与认知功能之间的关系。方法:在MEDLINE、SCOPUS、CINAHL、AgeLine中检索自成立至2020年10月的文献,不限制发表年份。观察性研究将年龄大于或等于60岁的老年人中蛋白质摄入量和认知功能的关联作为主要或次要结果进行调查。结果:定性分析包括9项横断面研究,共调查了4929名老年人。在6项研究中检查了整体认知功能。四项调查报告无关联,两项研究发现高蛋白摄入量的老年人比同龄人具有更高的全球认知功能。荟萃分析的结果表明,无论性别如何,老年人的蛋白质摄入量与整体认知功能之间没有显着关联。三项研究调查了其他认知领域。在所有的研究中,记忆力与蛋白质摄入量呈显著正相关。此外,在每项研究中,视觉空间、语言流畅性、处理速度和持续注意力都与蛋白质消耗呈正相关。结论:在定性和定量分析中均未观察到蛋白质摄入与整体认知功能之间的显著关联。蛋白质摄入与多种其他认知领域之间的关系也被测试。总体而言,3项研究报告了高蛋白摄入与记忆之间的显著正相关,而1项研究发现高蛋白摄入与视觉空间、语言流畅性、处理速度和持续注意力之间存在显著正相关。
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来源期刊
Nutrition and Metabolic Insights
Nutrition and Metabolic Insights NUTRITION & DIETETICS-
CiteScore
3.30
自引率
0.00%
发文量
27
审稿时长
8 weeks
期刊介绍: Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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