Characteristics and outcomes of patients with COVID-19 and liver injury: a retrospective analysis and a multicenter experience.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-03-17 Print Date: 2022-03-01 DOI:10.2478/rjim-2021-0027
Andrei Voiosu, Adina Roman, Ruxandra Pop, Alina Boeriu, Cristiana Popp, Sabina Zurac, Theodor Voiosu, Daniela Dobru, Bogdan Mateescu
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引用次数: 4

Abstract

Background and aims. Patients with COVID-19 frequently present abnormal elevated liver function tests of unknown clinical significance. We aimed to investigate the characteristics and factors influencing outcome in patients with confirmed SARS-CoV-2 infection and liver injury on admission.Methods. This is a retrospective observational study of patients hospitalized in two COVID units in Romania. Relevant data on clinical and laboratory parameters and medication administered during the admission were analyzed to identify predictors of a negative outcome. Patients with confirmed COVID-19 and liver function tests (LFTs) above the upper limit of normal were included in the analysis.Results. From 1,207 patients, we identified 134 patients (11%) with abnormal LFTs during hospitalization. The majority of patients had mildly elevated levels and a predominantly cholestatic pattern of liver injury. Patients who received lopinavir/ritonavir were more likely to have increased ALAT levels (p<0.0001). Sixteen patients had pre-existing chronic liver disease, and they were more likely to suffer from severe COVID-19 (p=0.009) and have a negative outcome (p<0.001), but on multivariate analysis, only the severity of COVID-19 was predictive of death (OR 69.9; 95% CI 6.4-761.4).Conclusions. Mild liver injury is relatively common in COVID-19 and possibly influenced by medication. Patients with chronic liver disease are at high risk for negative outcome, but the severity of the infection is the only predictor of death.

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COVID-19合并肝损伤患者的特征和结局:回顾性分析和多中心经验
背景和目的。COVID-19患者经常出现临床意义不明的肝功能检查异常升高。目的探讨确诊的SARS-CoV-2感染合并肝损伤患者入院时的特点及影响转归的因素。这是一项对罗马尼亚两个COVID住院患者的回顾性观察研究。对入院期间的临床和实验室参数及用药的相关数据进行分析,以确定阴性结果的预测因素。纳入确诊COVID-19且肝功能检查(LFTs)高于正常上限的患者。从1207例患者中,我们发现134例(11%)患者在住院期间出现异常LFTs。大多数患者有轻度升高的水平和主要的胆汁淤积型肝损伤。接受洛匹那韦/利托那韦治疗的患者ALAT水平升高的可能性更大。轻度肝损伤在COVID-19中相对常见,可能受药物影响。慢性肝病患者出现阴性结果的风险很高,但感染的严重程度是死亡的唯一预测因素。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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