Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Rambam Maimonides Medical Journal Pub Date : 2021-07-20 DOI:10.5041/RMMJ.10443
François-Pantaléon Musungayi Kajingulu, François Bompeka Lepira, Aliocha Natuhoyila Nkodila, Jean-Robert Rissassy Makulo, Vieux Momeme Mokoli, Pepe Mfutu Ekulu, Justine Busanga Bukabau, Yannick Mayamba Nlandu, Augustin Luzayadio Longo, Nazaire Mangani Nseka, Ernest Kiswaya Sumaili
{"title":"Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Levels Predict Future Cardiovascular Event Risks in Hemodialyzed Black African Patients.","authors":"François-Pantaléon Musungayi Kajingulu,&nbsp;François Bompeka Lepira,&nbsp;Aliocha Natuhoyila Nkodila,&nbsp;Jean-Robert Rissassy Makulo,&nbsp;Vieux Momeme Mokoli,&nbsp;Pepe Mfutu Ekulu,&nbsp;Justine Busanga Bukabau,&nbsp;Yannick Mayamba Nlandu,&nbsp;Augustin Luzayadio Longo,&nbsp;Nazaire Mangani Nseka,&nbsp;Ernest Kiswaya Sumaili","doi":"10.5041/RMMJ.10443","DOIUrl":null,"url":null,"abstract":"<p><strong>Context and objective: </strong>Cardiovascular diseases are the leading cause of mortality in patients. In this context, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to be the new biomarker identified as interfering in lipid homeostasis. This study aimed to investigate the association between PCSK9, dyslipidemia, and future risk of cardiovascular events in a population of black Africans.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between August 2016 and July 2020 in six hemodialysis centers in the city of Kinshasa, Democratic Republic of the Congo. Serum PCSK9 was measured by ELISA; lipid levels of 251 chronic kidney disease grade 5 (CKD G5) hemodialysis patients and the Framingham predictive instrument were used for predicting cardiac events.</p><p><strong>Results: </strong>Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) were significantly increased in the tertile with the highest PCSK9. By contrast, high-density lipoprotein cholesterol (HDL-c) was significantly decreased in the same tertile. A strong positive and significant correlation was found between PCSK9 and TC, TG, and LDL-c. Negative and significant correlation was observed between PCSK9 and HDL-c. The levels of PCSK9, smoking, overweight, and atherogenic dyslipidemia were associated with future risks for cardiovascular events in univariate analysis. After adjustment, all these variables persisted as independent determinants of future risk for cardiovascular events. The probability of having a cardiovascular event in this population was independently associated with PCSK9 levels. Compared to the patients in the lowest PCSK9 tertile, patients with PCSK9 levels in the middle (aOR 5.9, 95% CI 2.06-17.3, P<0.001) and highest tertiles (aOR 8.9, 95% CI 3.02-25.08, P<0.001) presented a greater risk of cardiac event.</p><p><strong>Conclusion: </strong>Increased PCSK9 serum levels are associated with higher levels of TC, LDL-c, and TG and lower levels of HDL-c in black African hemodialysis patients. Serum PCSK9 levels in these patients predict increased risk of cardiovascular events, independent of traditional potential confounders.</p>","PeriodicalId":46408,"journal":{"name":"Rambam Maimonides Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284989/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rambam Maimonides Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5041/RMMJ.10443","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 2

Abstract

Context and objective: Cardiovascular diseases are the leading cause of mortality in patients. In this context, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to be the new biomarker identified as interfering in lipid homeostasis. This study aimed to investigate the association between PCSK9, dyslipidemia, and future risk of cardiovascular events in a population of black Africans.

Methods: A cross-sectional study was conducted between August 2016 and July 2020 in six hemodialysis centers in the city of Kinshasa, Democratic Republic of the Congo. Serum PCSK9 was measured by ELISA; lipid levels of 251 chronic kidney disease grade 5 (CKD G5) hemodialysis patients and the Framingham predictive instrument were used for predicting cardiac events.

Results: Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) were significantly increased in the tertile with the highest PCSK9. By contrast, high-density lipoprotein cholesterol (HDL-c) was significantly decreased in the same tertile. A strong positive and significant correlation was found between PCSK9 and TC, TG, and LDL-c. Negative and significant correlation was observed between PCSK9 and HDL-c. The levels of PCSK9, smoking, overweight, and atherogenic dyslipidemia were associated with future risks for cardiovascular events in univariate analysis. After adjustment, all these variables persisted as independent determinants of future risk for cardiovascular events. The probability of having a cardiovascular event in this population was independently associated with PCSK9 levels. Compared to the patients in the lowest PCSK9 tertile, patients with PCSK9 levels in the middle (aOR 5.9, 95% CI 2.06-17.3, P<0.001) and highest tertiles (aOR 8.9, 95% CI 3.02-25.08, P<0.001) presented a greater risk of cardiac event.

Conclusion: Increased PCSK9 serum levels are associated with higher levels of TC, LDL-c, and TG and lower levels of HDL-c in black African hemodialysis patients. Serum PCSK9 levels in these patients predict increased risk of cardiovascular events, independent of traditional potential confounders.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
循环蛋白转化酶枯草杆菌素/可辛9型水平预测血液透析黑人患者未来心血管事件风险
背景和目的:心血管疾病是患者死亡的主要原因。在这种情况下,蛋白转化酶枯草素/酮蛋白9型(PCSK9)似乎是被鉴定为干扰脂质稳态的新生物标志物。本研究旨在调查非洲黑人人群中PCSK9、血脂异常和未来心血管事件风险之间的关系。方法:2016年8月至2020年7月,在刚果民主共和国金沙萨市的六个血液透析中心进行了一项横断面研究。ELISA法检测血清PCSK9;251例慢性肾脏疾病5级(CKD G5)血液透析患者的血脂水平和Framingham预测仪用于预测心脏事件。结果:总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)和甘油三酯(TG)在PCSK9最高的小鼠中显著升高。相比之下,同一品种的高密度脂蛋白胆固醇(HDL-c)显著降低。PCSK9与TC、TG、LDL-c呈显著正相关。PCSK9与HDL-c呈显著负相关。在单变量分析中,PCSK9水平、吸烟、超重和动脉粥样硬化性血脂异常与心血管事件的未来风险相关。调整后,所有这些变量仍然是未来心血管事件风险的独立决定因素。该人群发生心血管事件的概率与PCSK9水平独立相关。与PCSK9水平最低的患者相比,PCSK9水平处于中等水平的患者(aOR 5.9, 95% CI 2.06-17.3)。结论:在非洲黑人血液透析患者中,PCSK9血清水平升高与TC、LDL-c和TG水平升高以及HDL-c水平降低相关。这些患者的血清PCSK9水平预测心血管事件风险增加,独立于传统的潜在混杂因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
期刊最新文献
IgG4-related Breast Disease: Review of the Literature. Inpatient Rehabilitation is Effective for Severe Daily Activity Deficits Related to Chronic Low Back Pain. Kidnapped But Not Kids: A Case Series of Three Octogenarian Hostages Held in Captivity by Hamas. Myxedema Coma-associated Pancytopenia: A Case Report. The Medical Professional Elimination Program and the Ideology and Motivation of Nazi Physicians.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1