Structural connectivity changes in the motor execution network after stroke rehabilitation.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2021-01-01 DOI:10.3233/RNN-211148

Pradeepa Ruwan Wanni Arachchige, Sadhani Karunarathna, Abdul Chalik Meidian, Ryo Ueda, Wataru Uchida, Masahiro Abo, Atsushi Senoo

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引用次数: 2

Abstract

Background: Although quite a very few studies have tested structural connectivity changes following an intervention, it reflects only selected key brain regions in the motor network. Thus, the understanding of structural connectivity changes related to the motor recovery process remains unclear.

Objective: This study investigated structural connectivity changes of the motor execution network following a combined intervention of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) and intensive occupational therapy (OT) after a stroke using graph theory approach.

Methods: Fifty-six stroke patients underwent Fugl-Meyer Assessment (FMA), Wolf Motor Function Test-Functional Ability Scale (WMFT-FAS), diffusion tensor imaging (DTI), and T1 weighted imaging before and after the intervention. We examined graph theory measures related to twenty brain regions using structural connectomes.

Results: The ipsilesional and contralesional hemisphere showed structural connectivity changes post-intervention after stroke. We found significantly increased regional centralities and nodal efficiency within the frontal pole and decreased degree centrality and nodal efficiency in the ipsilesional thalamus. Correlations were found between network measures and clinical assessments in the cuneus, postcentral gyrus, precentral gyrus, and putamen of the ipsilesional hemisphere. The contralesional areas such as the caudate, cerebellum, and frontal pole also showed significant correlations.

Conclusions: This study was helpful to expand the understanding of structural connectivity changes in both hemispheric networks during the motor recovery process following LF-rTMS and intensive OT after stroke.

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脑卒中康复后运动执行网络结构连通性的改变。

背景:虽然很少有研究测试了干预后的结构连接变化，但它只反映了运动网络中选定的关键大脑区域。因此，对与运动恢复过程相关的结构连通性变化的理解仍不清楚。目的:利用图论方法研究低频重复经颅磁刺激(LF-rTMS)和强化作业治疗(OT)联合干预脑卒中后运动执行网络的结构连通性变化。方法:56例脑卒中患者在干预前后分别进行Fugl-Meyer评估(FMA)、Wolf运动功能测试(WMFT-FAS)、弥散张量成像(DTI)和T1加权成像。我们使用结构连接体检查了与20个大脑区域相关的图论测量。结果:脑卒中后同侧半球和对侧半球结构连通性发生改变。我们发现额极的区域中心性和节效率显著增加，同侧丘脑的度中心性和节效率显著降低。在同侧半球的楔骨、中央后回、中央前回和壳核中发现了网络测量与临床评估之间的相关性。对侧脑区如尾状、小脑和额极也表现出显著的相关性。结论:本研究有助于扩大对脑卒中后LF-rTMS和强化OT后运动恢复过程中两个半球网络结构连通性变化的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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