The Ends Dictate the Means: Promoter Switching in Herpesvirus Gene Expression.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2021-09-29 Epub Date: 2021-06-15 DOI:10.1146/annurev-virology-091919-072841
Andrew E Hale, Nathaniel J Moorman
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引用次数: 3

Abstract

Herpesvirus gene expression is dynamic and complex, with distinct complements of viral genes expressed at specific times in different infection contexts. These complex patterns of viral gene expression arise in part from the integration of multiple cellular and viral signals that affect the transcription of viral genes. The use of alternative promoters provides an increased level of control, allowing different promoters to direct the transcription of the same gene in response to distinct temporal and contextual cues. While once considered rare, herpesvirus alternative promoter usage was recently found to be far more pervasive and impactful than previously thought. Here we review several examples of promoter switching in herpesviruses and discuss the functional consequences on the transcriptional and post-transcriptional regulation of viral gene expression.

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目的决定手段:疱疹病毒基因表达中的启动子转换。
疱疹病毒的基因表达是动态和复杂的,在不同的感染背景下,在特定的时间表达不同的病毒基因。这些病毒基因表达的复杂模式部分源于影响病毒基因转录的多种细胞和病毒信号的整合。替代启动子的使用提供了更高的控制水平,允许不同的启动子根据不同的时间和上下文提示来指导同一基因的转录。虽然一度被认为是罕见的,但最近发现疱疹病毒替代启动子的使用比以前认为的要普遍和有影响力得多。在这里,我们回顾了疱疹病毒启动子开关的几个例子,并讨论了病毒基因表达的转录和转录后调控的功能后果。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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