Dupilumab elicits a favorable response in type-2 inflammatory comorbidities of severe atopic dermatitis.

Pub Date : 2021-06-16 DOI:10.1186/s12948-021-00144-x
Eustachio Nettis, Lucia Masciopinto, Elisabetta Di Leo, Nicola De Candia, Marcello Albanesi, Danilo Di Bona, Nicola Quaranta, Luigi Macchia
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Abstract

Background: This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects.

Case presentation: We report on effects of dupilumab in a patient with severe AD, a long-standing history of a mild, perennial allergic rhino-conjunctivitis, moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).

Conclusions: Patients suffering from AD, asthma, allergic rhinitis and CRSwNP may be eligible for dupilumab single treatment that is possibly advantageous also from the pharmaco-economic standpoint.

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杜匹单抗对严重特应性皮炎的 2 型炎症合并症产生了良好的反应。
背景:本病例是首次报道用杜比单抗快速、成功地治疗同一患者的重度特应性皮炎(AD)和合并的2型炎症性疾病,且无副作用:我们报告了双鲁单抗对一名患有严重特应性皮炎、长期轻度过敏性鼻结膜炎、中度哮喘和慢性鼻炎伴鼻息肉(CRSwNP)的患者的治疗效果:结论:患有自闭症、哮喘、过敏性鼻炎和慢性鼻炎伴鼻息肉(CRSwNP)的患者可能有资格接受杜必鲁单抗的单一治疗,从药物经济学的角度来看,这可能也是有利的。
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