Nephrogenic systemic fibrosis: A frivolous entity.

Vinant Bhargava, Kulwant Singh, Priti Meena, Rupan Sanyal
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引用次数: 17

Abstract

Gadolinium-based contrast agents (GBCAs) used in magnetic resonance imaging are vital in providing enhanced quality images, essential for diagnosis and treatment. Nephrogenic systemic fibrosis (NSF) with GBCAs has been a deterrent for the physician and has led to avoidance of these agents in patients with impaired kidney function. NSF is a progressive debilitating multisystem condition described classically in patients with renal insufficiency exposed to gadolinium contrast media. It is characterized by an induration and hardening of the skin. NSF is described to first involve the extremities and can imperceptibly involve internal organs. Lack of therapeutic interventions to treat NSF makes it more challenging and warrants deep insight into the pathogenesis, risk factors and treatment strategies.

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肾源性全身性纤维化:一个无足轻重的实体。
磁共振成像中使用的钆基造影剂(gbca)对于提供高质量的图像至关重要,对诊断和治疗至关重要。肾源性全身性纤维化(NSF)与gbca一直是医生的威慑,并导致肾功能受损患者避免使用这些药物。NSF是一种进行性衰弱的多系统疾病,通常发生在暴露于钆造影剂的肾功能不全患者中。它的特点是皮肤硬化和硬化。NSF被描述为首先累及四肢,并可在不知不觉中累及内脏。缺乏治疗干预措施治疗NSF使其更具挑战性,需要深入了解发病机制,危险因素和治疗策略。
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