Hashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2021-11-20 Print Date: 2021-12-01 DOI:10.2478/rjim-2021-0023
Ozge Kurtkulagi, Burcin Meryem Atak Tel, Gizem Kahveci, Satilmis Bilgin, Tuba Taslamacioglu Duman, Asli Ertürk, Buse Balci, Gulali Aktas
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引用次数: 31

Abstract

Background. Hashimoto's thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol - so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. We aimed to compare UHR and other laboratory parameters of the patients with HT to those values in healthy controls. Methods. The patients diagnosed with HT by medical history, physical examination, elevated thyroid autoantibodies in serum and characteristic sonographic findings in outpatient internal medicine clinics of our institution were enrolled to the present retrospective study. Age and sex matched healthy volunteers were enrolled as controls. UHR of the HT patients and control subjects were compared. Results. The mean UHR of the HT group was 11% ± 4 %, while UHR of the control group was 8% ± 2% (p<0.001). UHR was significantly and positively correlated with thyroid stimulating hormone (TSH) (r=0.26, p=0.01) and negatively correlated with free T4 (FT4) (r=-0.22, p=0.04) levels. The sensitivity and specificity of the UHR level were greater than 8.3%: were 74% and 52%, respectively (AUC: 0.74, p<0.001, 95% CI: 0.64-0.84). Conclusion. We suggest that UHR is a reliable and useful marker for HT. Therefore, it may be helpful in establishing the diagnosis of HT in addition to other diagnostic tools.

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桥本甲状腺炎与血清尿酸/高密度脂蛋白-胆固醇比值升高有关。
背景。桥本甲状腺炎(HT)是一种以甲状腺淋巴细胞和成纤维细胞浸润为特征的自身免疫性疾病。尿酸和高密度脂蛋白胆固醇的比率,即尿酸与高密度脂蛋白比率(UHR)在炎症性疾病中被证明会升高。我们的目的是比较HT患者的UHR和其他实验室参数与健康对照者的值。方法。本研究纳入我院门诊内科门诊经病史、体格检查、血清甲状腺自身抗体升高及超声特征性表现诊断为HT的患者。年龄和性别匹配的健康志愿者作为对照。比较HT患者与对照组的UHR。结果。治疗组平均UHR为11%±4%,对照组平均UHR为8%±2% (p。我们认为UHR是一种可靠和有用的HT标记。因此,除了其他诊断工具外,它可能有助于建立HT的诊断。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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