The repair gene BACH1 - a potential oncogene.

IF 3.1 Q2 ONCOLOGY Oncology Reviews Pub Date : 2021-07-02 eCollection Date: 2021-02-26 DOI:10.4081/oncol.2021.519
Katheeja Muhseena N, Sooraj Mathukkada, Shankar Prasad Das, Suparna Laha
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引用次数: 6

Abstract

BACH1 encodes for a protein that belongs to RecQ DEAH helicase family and interacts with the BRCT repeats of BRCA1. The N-terminus of BACH1 functions in DNA metabolism as DNA-dependent ATPase and helicase. The C-terminus consists of BRCT domain, which interacts with BRCA1 and this interaction is one of the major regulator of BACH1 function. BACH1 plays important roles both in phosphorylated as well as dephosphorylated state and functions in coordination with multiple signaling molecules. The active helicase property of BACH1 is maintained by its dephosphorylated state. Imbalance between these two states enhances the development and progression of the diseased condition. Currently BACH1 is known as a tumor suppressor gene based on the presence of its clinically relevant mutations in different cancers. Through this review we have justified it to be named as an oncogene. In this review, we have explained the mechanism of how BACH1 in collaboration with BRCA1 or independently regulates various pathways like cell cycle progression, DNA replication during both normal and stressed situation, recombination and repair of damaged DNA, chromatin remodeling and epigenetic modifications. Mutation and overexpression of BACH1 are significantly found in different cancer types. This review enlists the molecular players which interact with BACH1 to regulate DNA metabolic functions, thereby revealing its potential for cancer therapeutics. We have identified the most mutated functional domain of BACH1, the hot spot for tumorigenesis, justifying it as a target molecule in different cancer types for therapeutics. BACH1 has high potentials of transforming a normal cell into a tumor cell if compromised under certain circumstances. Thus, through this review, we justify BACH1 as an oncogene along with the existing role of being a tumor suppressant.

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修复基因BACH1 -一个潜在的致癌基因。
BACH1编码一种属于RecQ DEAH解旋酶家族的蛋白质,并与BRCA1的BRCT重复序列相互作用。BACH1的n端作为DNA依赖性atp酶和解旋酶在DNA代谢中起作用。c端由BRCT结构域组成,该结构域与BRCA1相互作用,这种相互作用是BACH1功能的主要调节因子之一。BACH1在磷酸化和去磷酸化状态下均发挥重要作用,并与多种信号分子协同作用。BACH1的活性解旋酶特性通过其去磷酸化状态得以维持。这两种状态之间的不平衡促进了疾病的发展和进展。目前,BACH1被认为是一种肿瘤抑制基因,基于其在不同癌症中存在的临床相关突变。通过这篇综述,我们证明它是一种致癌基因。在这篇综述中,我们解释了BACH1如何与BRCA1协同或独立调节细胞周期进程、正常和应激情况下的DNA复制、受损DNA的重组和修复、染色质重塑和表观遗传修饰等多种途径的机制。BACH1的突变和过表达在不同的癌症类型中均有显著的发现。本文综述了与BACH1相互作用调节DNA代谢功能的分子,从而揭示了BACH1在癌症治疗中的潜力。我们已经确定了BACH1最突变的功能域,这是肿瘤发生的热点,证明它是不同癌症类型治疗的靶分子。如果BACH1在某些情况下受损,它具有将正常细胞转化为肿瘤细胞的高电位。因此,通过这篇综述,我们证明BACH1是一种致癌基因,同时也是一种肿瘤抑制基因。
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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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