PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA.

IF 5.9 Q1 Computer Science Journal of Healthcare Informatics Research Pub Date : 2021-06-14 eCollection Date: 2021-09-01 DOI:10.1007/s41666-021-00099-3
Nitin Kamra, Yizhou Zhang, Sirisha Rambhatla, Chuizheng Meng, Yan Liu
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Abstract

Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a mathematical model, namely PolSIRD, which accounts for the under-reporting by introducing an observation mechanism. It also captures the effects of intervention policies on the disease spread parameters by leveraging intervention policy data along with the reported disease cases. Furthermore, we allow our recurrent model to learn the initial hidden state of all compartments end-to-end along with other parameters via gradient-based training. We apply our model to the spread of the recent global outbreak of COVID-19 in the USA, where our model outperforms the methods employed by the CDC in predicting the spread. We also provide counterfactual simulations from our model to analyze the effect of lifting the intervention policies prematurely and our model correctly predicts the second wave of the epidemic.

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PolSIRD:模拟干预政策下的流行病传播:分析美国第一波 COVID-19。
流行病在人群中的传播传统上是通过分区模型来模拟的,这些模型代表了在没有任何干预政策的情况下疾病的自由演变。此外,这些模型假定疾病病例可被完全观察到,但不考虑报告不足的情况。我们提出了一个数学模型,即 PolSIRD,该模型通过引入观察机制来考虑报告不足的问题。它还通过利用干预政策数据和报告的疾病病例,捕捉干预政策对疾病传播参数的影响。此外,我们还允许循环模型通过基于梯度的训练,端到端地学习所有分区的初始隐藏状态和其他参数。我们将模型应用于最近在美国爆发的 COVID-19 全球疫情的传播,我们的模型在预测疫情传播方面优于疾病预防控制中心采用的方法。我们还根据模型进行了反事实模拟,分析了过早解除干预政策的影响,我们的模型正确预测了第二波疫情。
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来源期刊
Journal of Healthcare Informatics Research
Journal of Healthcare Informatics Research Computer Science-Computer Science Applications
CiteScore
13.60
自引率
1.70%
发文量
12
期刊介绍: Journal of Healthcare Informatics Research serves as a publication venue for the innovative technical contributions highlighting analytics, systems, and human factors research in healthcare informatics.Journal of Healthcare Informatics Research is concerned with the application of computer science principles, information science principles, information technology, and communication technology to address problems in healthcare, and everyday wellness. Journal of Healthcare Informatics Research highlights the most cutting-edge technical contributions in computing-oriented healthcare informatics.  The journal covers three major tracks: (1) analytics—focuses on data analytics, knowledge discovery, predictive modeling; (2) systems—focuses on building healthcare informatics systems (e.g., architecture, framework, design, engineering, and application); (3) human factors—focuses on understanding users or context, interface design, health behavior, and user studies of healthcare informatics applications.   Topics include but are not limited to: ·         healthcare software architecture, framework, design, and engineering;·         electronic health records·         medical data mining·         predictive modeling·         medical information retrieval·         medical natural language processing·         healthcare information systems·         smart health and connected health·         social media analytics·         mobile healthcare·         medical signal processing·         human factors in healthcare·         usability studies in healthcare·         user-interface design for medical devices and healthcare software·         health service delivery·         health games·         security and privacy in healthcare·         medical recommender system·         healthcare workflow management·         disease profiling and personalized treatment·         visualization of medical data·         intelligent medical devices and sensors·         RFID solutions for healthcare·         healthcare decision analytics and support systems·         epidemiological surveillance systems and intervention modeling·         consumer and clinician health information needs, seeking, sharing, and use·         semantic Web, linked data, and ontology·         collaboration technologies for healthcare·         assistive and adaptive ubiquitous computing technologies·         statistics and quality of medical data·         healthcare delivery in developing countries·         health systems modeling and simulation·         computer-aided diagnosis
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