{"title":"Application of pooled testing in estimating the prevalence of COVID-19.","authors":"Pritha Guha, Apratim Guha, Tathagata Bandyopadhyay","doi":"10.1007/s10742-021-00258-4","DOIUrl":null,"url":null,"abstract":"<p><p>Testing at a mass scale has been widely accepted as an effective way to contain the spread of the SARS-CoV-2 Virus. In the initial stages, the shortage of test kits severely restricted mass-scale testing. Pooled testing was offered as a partial solution to this problem. However, it is a relatively lesser-known fact that pooled testing can also result in significant gains, both in terms of cost savings as well as measurement accuracy, in prevalence estimation surveys. We review here the statistical theory of pooled testing for screening as well as for prevalence estimation. We study the impact of the diagnostic errors, and misspecification of the sensitivity and the specificity on the performances of the pooled as well as individual testing procedures. Our investigation clarifies some of the issues hotly debated in the context of COVID-19 and shows the potential gains for the Indian Council for Medical Research (ICMR) in using a pooled sampling for their upcoming COVID-19 prevalence surveys.</p>","PeriodicalId":45600,"journal":{"name":"Health Services and Outcomes Research Methodology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349243/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Services and Outcomes Research Methodology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10742-021-00258-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/8/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 3
Abstract
Testing at a mass scale has been widely accepted as an effective way to contain the spread of the SARS-CoV-2 Virus. In the initial stages, the shortage of test kits severely restricted mass-scale testing. Pooled testing was offered as a partial solution to this problem. However, it is a relatively lesser-known fact that pooled testing can also result in significant gains, both in terms of cost savings as well as measurement accuracy, in prevalence estimation surveys. We review here the statistical theory of pooled testing for screening as well as for prevalence estimation. We study the impact of the diagnostic errors, and misspecification of the sensitivity and the specificity on the performances of the pooled as well as individual testing procedures. Our investigation clarifies some of the issues hotly debated in the context of COVID-19 and shows the potential gains for the Indian Council for Medical Research (ICMR) in using a pooled sampling for their upcoming COVID-19 prevalence surveys.
期刊介绍：
The journal reflects the multidisciplinary nature of the field of health services and outcomes research. It addresses the needs of multiple, interlocking communities, including methodologists in statistics, econometrics, social and behavioral sciences; designers and analysts of health policy and health services research projects; and health care providers and policy makers who need to properly understand and evaluate the results of published research. The journal strives to enhance the level of methodologic rigor in health services and outcomes research and contributes to the development of methodologic standards in the field. In pursuing its main objective, the journal also provides a meeting ground for researchers from a number of traditional disciplines and fosters the development of new quantitative, qualitative, and mixed methods by statisticians, econometricians, health services researchers, and methodologists in other fields. Health Services and Outcomes Research Methodology publishes: Research papers on quantitative, qualitative, and mixed methods; Case Studies describing applications of quantitative and qualitative methodology in health services and outcomes research; Review Articles synthesizing and popularizing methodologic developments; Tutorials; Articles on computational issues and software reviews; Book reviews; and Notices. Special issues will be devoted to papers presented at important workshops and conferences.
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