The Relationship Between Insulin Use And Increased Mortality In Patients With COVID-19 And Diabetes: A Meta-Analysis.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2022-02-01 Epub Date: 2021-08-19 DOI:10.1080/07435800.2021.1967376

Wanteng Wang, Yu Sun, Shuai Wang, Yunbo Sun

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引用次数: 1

Abstract

Purpose: The purpose of this study is to review observational studies on the effect of insulin use and mortality in patients with COVID-19 and diabetes.

Methods: A systematic literature search was performed using the PubMed, Medline, EMBASE, and Cochrane Library databases. The meta-analysis was performed using a random effects model, and I² was applied to evaluate heterogeneity. Sensitivity and subgroup analyses were also performed.

Results: Overall, 1,338 patients over six studies were ultimately included. Insulin use was related to a higher risk of death in diabetic patients with COVID-19 compared to those who did not use insulin (odds ratio: 2.59, 95% confidence interval: 1.66-4.05; P < .0001; I²: 57%).

Conclusions: This meta-analysis revealed a correlation between insulin usage and increased mortality in diabetic patients with COVID-19. These results showed that insulin requirement in patients with COVID-19 and diabetes might indicate a poor prognosis.

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COVID-19和糖尿病患者胰岛素使用与死亡率增加之间的关系:一项荟萃分析

目的:本研究的目的是回顾观察性研究对胰岛素使用和COVID-19合并糖尿病患者死亡率的影响。方法:使用PubMed、Medline、EMBASE和Cochrane图书馆数据库进行系统的文献检索。meta分析采用随机效应模型，I2用于评价异质性。还进行了敏感性和亚组分析。结果:总体而言，6项研究最终纳入了1338名患者。与未使用胰岛素的患者相比，糖尿病合并COVID-19患者使用胰岛素与更高的死亡风险相关(优势比:2.59,95%可信区间:1.66-4.05;P: 57%)。结论:该荟萃分析揭示了糖尿病合并COVID-19患者胰岛素使用与死亡率增加之间的相关性。这些结果表明，COVID-19合并糖尿病患者的胰岛素需求可能预示着预后不良。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.