Clinicopathological Examination of Metaplastic Spindle Cell Carcinoma of the Breast: Case Series.

IF 1.8 Q3 ONCOLOGY Breast Cancer : Basic and Clinical Research Pub Date : 2021-08-14 eCollection Date: 2021-01-01 DOI:10.1177/11782234211039433
Yumiko Ishizuka, Yoshiya Horimoto, Naotake Yanagisawa, Atsushi Arakawa, Katsuya Nakai, Mitsue Saito
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Abstract

Background: Spindle cell carcinoma (SpCC) of the breast is a rare histological type, a subtype of metaplastic carcinoma characterized by atypical spindle cell and epithelial carcinoma. The proportions of the spindle cell and epithelial components vary among tumours. Due to its rarity, biological characteristics of this disease have been poorly studied.

Methods: In total, 10 patients with SpCC were surgically treated at our institution from January 2007 to December 2018. We retrospectively investigated these SpCC cases, focusing on the differences between spindle cell and epithelial components. Microsatellite status was also examined.

Results: Nine cases were triple-negative breast cancer (TNBC). The rates of high tumour grade were 70% in spindle cell components and 56% in epithelial components (P = .65), while the mean Ki67 labelling index were 63% and 58%, respectively (P = .71). Mean programmed death ligand 1 (PD-L1) expression in these components was 11% and 1%, respectively (P = .20). All 10 tumours were microsatellite stable. Patient outcomes of triple-negative SpCC did not differ from those of propensity-matched patients with conventional TNBC.

Conclusions: Spindle cell components showed higher values in factors examined, although there was no statistically significant difference. Our data reveal that these 2 components of SpCC may be of different biological nature.

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乳腺化生梭形细胞癌的临床病理检查:病例系列。
背景:乳腺梭形细胞癌(SpCC)是一种罕见的组织学类型,是一种以非典型梭形细胞癌和上皮癌为特征的化生癌亚型。梭形细胞和上皮成分的比例因肿瘤而异。由于罕见,该病的生物学特性研究甚少。方法:2007年1月至2018年12月,我院共收治10例SpCC患者。我们回顾性调查了这些SpCC病例,重点研究纺锤形细胞和上皮成分之间的差异。还审查了微卫星状况。结果:三阴性乳腺癌(TNBC) 9例。梭形细胞成分和上皮成分的高肿瘤分级率分别为70%和56% (P = 0.65),平均Ki67标记指数分别为63%和58% (P = 0.71)。这些成分中程序性死亡配体1 (PD-L1)的平均表达量分别为11%和1% (P = 0.20)。10个肿瘤均微卫星稳定。三阴性SpCC患者的预后与倾向匹配的传统TNBC患者没有差异。结论:纺锤体细胞成分在检查的因素中显示更高的值,尽管没有统计学上的显著差异。我们的数据显示,SpCC的这两种成分可能具有不同的生物学性质。
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来源期刊
CiteScore
5.10
自引率
3.40%
发文量
22
审稿时长
8 weeks
期刊介绍: Breast Cancer: Basic and Clinical Research is an international, open access, peer-reviewed, journal which considers manuscripts on all areas of breast cancer research and treatment. We welcome original research, short notes, case studies and review articles related to breast cancer-related research. Specific areas of interest include, but are not limited to, breast cancer sub types, pathobiology, metastasis, genetics and epigenetics, mammary gland biology, breast cancer models, prevention, detection, therapy and clinical interventions, and epidemiology and population genetics.
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