Efficacy of platelet-rich fibrin on bone formation, part 2: Guided bone regeneration, sinus elevation and implant therapy.

Masako Fujioka-Kobayashi, Richard J Miron, Vittorio Moraschini, Yufeng Zhang, Reinhard Gruber, Hom-Lay Wang
{"title":"Efficacy of platelet-rich fibrin on bone formation, part 2: Guided bone regeneration, sinus elevation and implant therapy.","authors":"Masako Fujioka-Kobayashi,&nbsp;Richard J Miron,&nbsp;Vittorio Moraschini,&nbsp;Yufeng Zhang,&nbsp;Reinhard Gruber,&nbsp;Hom-Lay Wang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of platelet-rich fibrin on bone formation by investigating its use in guided bone regeneration, sinus elevation and implant therapy.</p><p><strong>Materials and methods: </strong>This systematic review and meta-analysis were conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The eligibility criteria comprised human controlled clinical trials comparing the clinical outcomes of platelet-rich fibrin with those of other treatment modalities. The outcomes measured included percentage of new bone formation, percentage of residual bone graft, implant survival rate, change in bone dimension (horizontal and vertical), and implant stability quotient values.</p><p><strong>Results: </strong>From 320 articles identified, 18 studies were included. Owing to the heterogeneity of the investigated parameters, a meta-analysis was only possible for sinus elevation. There is a general lack of data from comparative randomised clinical trials evaluating platelet-rich fibrin for guided bone regeneration procedures (only two studies), with no quantifiable advantages in terms of new bone formation or dimensional bone gain found in the platelet-rich fibrin group. For sinus elevation, the meta-analysis demonstrated no advantage in terms of histological new bone formation in the control group (bone graft alone) compared with the test group (bone graft and platelet-rich fibrin). Two studies demonstrated that platelet-rich fibrin may shorten healing periods prior to implant placement. Platelet-rich fibrin was also shown to slightly enhance primary implant stability (implant stability quotient value < 5) as assessed using implant stability quotients and resonance frequency analysis parameters, with no histological data evaluating bone-implant contact yet available on this topic. In one study, platelet-rich fibrin was shown to improve the clinical parameters when utilised as an adjunct for the treatment of peri-implantitis.</p><p><strong>Conclusions: </strong>In the majority of studies, platelet-rich fibrin offered little or no clear advantage in terms of new bone formation as evaluated in various studies on guided bone regeneration and sinus elevation, nor in implant stability and treatment of peri-implantitis. Various authors and systematic reviews on the topic have now expressed criticism of the various study designs and protocols, and the lack of appropriate controls and available information regarding patient selection. Well-controlled human studies on these specific topics are required.</p>","PeriodicalId":73463,"journal":{"name":"International journal of oral implantology (Berlin, Germany)","volume":"14 3","pages":"285-302"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of oral implantology (Berlin, Germany)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: To investigate the effect of platelet-rich fibrin on bone formation by investigating its use in guided bone regeneration, sinus elevation and implant therapy.

Materials and methods: This systematic review and meta-analysis were conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The eligibility criteria comprised human controlled clinical trials comparing the clinical outcomes of platelet-rich fibrin with those of other treatment modalities. The outcomes measured included percentage of new bone formation, percentage of residual bone graft, implant survival rate, change in bone dimension (horizontal and vertical), and implant stability quotient values.

Results: From 320 articles identified, 18 studies were included. Owing to the heterogeneity of the investigated parameters, a meta-analysis was only possible for sinus elevation. There is a general lack of data from comparative randomised clinical trials evaluating platelet-rich fibrin for guided bone regeneration procedures (only two studies), with no quantifiable advantages in terms of new bone formation or dimensional bone gain found in the platelet-rich fibrin group. For sinus elevation, the meta-analysis demonstrated no advantage in terms of histological new bone formation in the control group (bone graft alone) compared with the test group (bone graft and platelet-rich fibrin). Two studies demonstrated that platelet-rich fibrin may shorten healing periods prior to implant placement. Platelet-rich fibrin was also shown to slightly enhance primary implant stability (implant stability quotient value < 5) as assessed using implant stability quotients and resonance frequency analysis parameters, with no histological data evaluating bone-implant contact yet available on this topic. In one study, platelet-rich fibrin was shown to improve the clinical parameters when utilised as an adjunct for the treatment of peri-implantitis.

Conclusions: In the majority of studies, platelet-rich fibrin offered little or no clear advantage in terms of new bone formation as evaluated in various studies on guided bone regeneration and sinus elevation, nor in implant stability and treatment of peri-implantitis. Various authors and systematic reviews on the topic have now expressed criticism of the various study designs and protocols, and the lack of appropriate controls and available information regarding patient selection. Well-controlled human studies on these specific topics are required.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
富血小板纤维蛋白对骨形成的影响,第二部分:引导骨再生、窦抬高和种植体治疗。
目的:探讨富血小板纤维蛋白在引导骨再生、窦抬高和种植体治疗中的应用,探讨其对骨形成的影响。材料和方法:本系统评价和荟萃分析按照系统评价和荟萃分析指南的首选报告项目进行和报告。入选标准包括人类对照临床试验,比较富血小板纤维蛋白与其他治疗方式的临床结果。测量的结果包括新骨形成百分比、残余骨移植物百分比、种植体存活率、骨尺寸变化(水平和垂直)以及种植体稳定性商值。结果:从320篇文献中,纳入了18项研究。由于所调查参数的异质性,荟萃分析仅适用于窦抬高。目前普遍缺乏评价富血小板纤维蛋白用于引导骨再生手术的比较随机临床试验的数据(只有两项研究),在新骨形成或骨尺寸增加方面,富血小板纤维蛋白组没有可量化的优势。对于窦抬高,荟萃分析显示,对照组(仅植骨)与试验组(植骨和富血小板纤维蛋白)相比,在组织学新骨形成方面没有优势。两项研究表明,富含血小板的纤维蛋白可以缩短植入前的愈合时间。通过种植体稳定商和共振频率分析参数评估,富血小板纤维蛋白也显示出轻微增强初级种植体稳定性(种植体稳定商值< 5),目前尚无关于该主题评估骨-种植体接触的组织学数据。在一项研究中,富血小板纤维蛋白被证明可以改善临床参数,当用作治疗种植体周围炎的辅助手段时。结论:在大多数研究中,富血小板纤维蛋白在引导骨再生和窦抬高方面的新骨形成方面几乎没有或没有明显的优势,在种植体稳定性和种植体周围炎的治疗方面也没有明显的优势。关于该主题的许多作者和系统综述现在对各种研究设计和方案以及缺乏适当的控制和关于患者选择的可用信息表示了批评。需要对这些特定主题进行控制良好的人体研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Dental implants versus removable prostheses for the management of edentulous sites in patients with florid cemento-osseous dysplasia: A systematic review of literature with a follow-up period of at least 3 years. Effect of the mesiodistal cantilever on implant-supported single crowns on biological and technical complications: A retrospective study. Setting up our patients' dental implants for long-term success. Submerged vertical bone augmentation of supraosseous peri-implant defects. The adjunctive use of systemic antibiotics in the non-surgical and surgical treatment of peri-implantitis: A systematic review and meta-analysis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1