Relationship between endocrine resistance and the periods of adjuvant endocrine treatment for hormone receptor-positive, HER2-negative breast cancer.

Breast disease Pub Date : 2022-01-01 DOI:10.3233/BD-210027

Jun Yamamura, Yukiko Miyamura, Shunji Kamigaki, Junya Fujita, Hiroki Osato, Hironobu Manabe, Yumiko Tanaka, Wataru Shinzaki, Yukihiko Hahimot, Toshikazu Ito, Yoshifumi Komoike

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Abstract

Background: Current guidelines define primary and secondary endocrine resistance according to the periods of adjuvant endocrine therapy (adj-ET); however, the relationship between adj-ET period and endocrine resistance remains unclear.

Objective: We examined progression-free survival (PFS) after primary ET for recurrent hormone receptor-positive/HER2-negative breast cancer, and evaluated the relationship between endocrine resistance and the periods of adj-ET.

Methods: We assessed PFS among 183 patients who received ET as primary treatment for the first recurrence, according to the period of adj-ET (adj-ET < 1 year, 1-2 years, ≥2 years, and completion).

Results: Patients who relapsed during the first year of adj-ET had the significantly shortest PFS. PFS did not significantly differ between patients who relapsed at 1-2 years of adj-ET and patients who relapsed while on adj-ET but after the first 2 years.

Conclusions: Relapse at 1-2 years after adj-ET initiation might be better classified as secondary endocrine resistance rather than primary endocrine resistance.

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激素受体阳性、her2阴性乳腺癌的内分泌抵抗与辅助内分泌治疗周期的关系

背景:目前的指南根据辅助内分泌治疗(adjet)的时间来定义原发性和继发性内分泌抵抗;然而，et期与内分泌抵抗的关系尚不清楚。目的:研究复发性激素受体阳性/ her2阴性乳腺癌原发性ET治疗后的无进展生存期(PFS)，并评估内分泌抵抗与ET治疗时间之间的关系。方法:我们评估了183例首次复发接受ET作为主要治疗的患者的PFS，根据ET的持续时间(ET < 1年，1-2年，≥2年和完成)。结果:在adj-ET治疗的第一年复发的患者PFS明显最短。在adj-ET治疗1-2年复发的患者和adj-ET治疗2年后复发的患者之间，PFS无显著差异。结论:adj-ET开始治疗后1-2年的复发可能更适合归类为继发性内分泌抵抗而不是原发性内分泌抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.