FOXP3 Predicts Response to Treatment in Mycosis Fungoides.

IF 0.6 4区医学 Q4 DERMATOLOGY Acta Dermatovenerologica Croatica Pub Date : 2021-07-01

Max Perelman, Mati Rozenblat, Eran Ellenbogen, Shamir Geller, Evgenya Slutsky Bank, Ori Eytan, Andrea Gat, Eli Sprecher, Ilan Goldberg

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Abstract

Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein 3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of previous studies are inconclusive.

Objective: We aimed at ascertaining the possibility that FOXP3 expression may serve to predict MF stage and response to therapy.

Patients and methods: Immunohistochemistry staining for FOXP3 was performed on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively graded. Disease stage, progression, and response to treatment were determined based on clinical and imaging evidence, and association with FOXP3 expression was assessed.

Results: FOXP3 expression in the dermis correlated with poor response to treatment (P=0.047). A negative non-significant relationship between epidermal FOXP3 expression and clinical stage severity was observed (P=0.17).

Conclusions: Dermal FOXP3 expression in MF lesions could be used to predict response to treatment in patients with MF.

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FOXP3预测真菌病治疗的反应。

背景:t -调节细胞(Tregs)标志物叉头盒蛋白3 (FOXP3)在蕈样真菌病(MF)发病机制中的作用尚不清楚，以往的研究结果尚无定论。目的:我们旨在确定FOXP3表达可能用于预测MF分期和治疗反应的可能性。患者和方法:对30例MF患者皮肤活检组织进行FOXP3免疫组化染色，并定量分级FOXP3表达水平。根据临床和影像学证据确定疾病分期、进展和对治疗的反应，并评估与FOXP3表达的关系。结果:真皮FOXP3表达与治疗效果差相关(P=0.047)。表皮FOXP3表达与临床分期严重程度呈负相关，无统计学意义(P=0.17)。结论:MF病变真皮FOXP3表达可用于预测MF患者对治疗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Dermatovenerologica Croatica 医学-皮肤病学

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Dermatovenerologica Croatica (ADC) aims to provide dermatovenerologists with up-to-date information on all aspects of the diagnosis and management of skin and venereal diseases. Accepted articles regularly include original scientific articles, short scientific communications, clinical articles, case reports, reviews, reports, news and correspondence. ADC is guided by a distinguished, international editorial board and encourages approach to continuing medical education for dermatovenerologists.