Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction

Xianyi Wang, Wanqiu Li, Shengdi Lu, Zhongliang Ma
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Abstract

Diabetic foot ulcers are seriously endangering the physical and mental health of patients. Due to the long duration of inflammation, the treatment of nonhealing wounds in diabetes is one of the most prominent healthcare problems in the world. The nuclear factor kappa B (NF-κB) signaling pathway, a classical pathway that triggers inflammatory response, is regulated by many regulators, such as glycogen synthase kinase 3 beta (GSK-3β). Noncoding RNAs, a large class of molecules that regulate gene expression at the posttranscriptional or posttranslational level, play an important role in various stages of wound healing, especially in the stage of inflammation. Herein, we summarized the roles of noncoding RNAs in the NF-κB/GSK-3β signaling, which might provide new ideas for the treatment of diabetic wound healing.

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非编码RNA相互作用和GSK-3β/NF-κB信号相互作用对伤口愈合的调节
糖尿病足溃疡严重危害患者的身心健康。由于炎症持续时间长,糖尿病患者伤口不愈合的治疗是世界上最突出的医疗保健问题之一。核因子κB (NF-κB)信号通路是引发炎症反应的经典途径,受糖原合成酶激酶3β (GSK-3β)等多种调节因子的调控。非编码rna是一类在转录后或翻译后水平调控基因表达的分子,在伤口愈合的各个阶段,特别是炎症阶段发挥着重要作用。本文总结了非编码rna在NF-κB/GSK-3β信号通路中的作用,为糖尿病创面愈合的治疗提供新的思路。
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Comparative and Functional Genomics
Comparative and Functional Genomics 生物-生化与分子生物学
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