Polymorphism in the HaeIII single nucleotide polymorphism of the SLC2A1 gene and cardiovascular disease in the early type 2 diabetes mellitus.

IF 3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes & Vascular Disease Research Pub Date : 2021-09-01 DOI:10.1177/14791641211041225

Dong-Hwa Lee, Gun Woo Won, Yong Hee Lee, Jong Sung Shin, Eu Jeong Ku, Tae Keun Oh, Hyun Jeong Jeon

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引用次数: 1

Abstract

Introduction: SLC2A1 polymorphism may play a role in the smooth muscle cell proliferation and extracellular matrix synthesis in vessels. However, the role of SLC2A1 polymorphism on diabetic cardiovascular disease (CVD) have not yet been identified. In this study, we aimed to investigate the association between SLC2A1 HaeIII polymorphism and CVD in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.

Methods: A total of 846 patients with T2DM who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of SLC2A1 gene was determined by real time polymerase chain reaction method. Genotyping results were presented GG, AG, or AA. Subgroup analysis was performed according to duration of T2DM (⩽10, 11-20, >20 years).

Results: The AA genotype was significantly associated with higher prevalence of CVD in patients with DM duration less than 10 years (26.3% vs 9.2%, p = 0.014). There was no significant association between SLC2A1 HaeIII polymorphism and other diabetic complications including, retinopathy, nephropathy, neuropathy, cerebrovascular disease, and peripheral artery disease.

Conclusions: The SLC2A1 HaeIII polymorphism was associated with CVD in Korean patients with T2DM with short disease duration.

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SLC2A1基因HaeIII单核苷酸多态性与早期2型糖尿病心血管疾病的关系

SLC2A1多态性可能在血管平滑肌细胞增殖和细胞外基质合成中起作用。然而，SLC2A1多态性在糖尿病心血管疾病(CVD)中的作用尚未确定。在这项研究中，我们的目的是研究SLC2A1 HaeIII多态性与韩国2型糖尿病(T2DM)患者病程的关系。方法:对在忠北大学医院就诊的T2DM患者846例进行调查。采用实时聚合酶链反应法检测SLC2A1基因HaeIII多态性。基因分型结果分别为GG、AG或AA。根据T2DM病程(≤10年、11-20年、>20年)进行亚组分析。结果:AA基因型与糖尿病病程小于10年的患者较高的CVD患病率显著相关(26.3% vs 9.2%， p = 0.014)。SLC2A1 HaeIII多态性与其他糖尿病并发症包括视网膜病变、肾病、神经病变、脑血管疾病和外周动脉疾病无显著相关性。结论:SLC2A1 HaeIII多态性与病程短的韩国T2DM患者的CVD相关。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)