Correlation between DVH parameters and lung function changes before and after radiotherapy and the occurrence of radiation induced lung injury (RILI).

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Neuro endocrinology letters Pub Date : 2021-09-10

Sha Sha, Jigang Dong, Maoyu Wang, Ziyu Chen, Peng Gao

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Abstract

Objective: To explore the correlation between dose volume histogram (DVH) parameters and lung function changes before and after radiotherapy and the occurrence of radiation-induced lung injury (RILI), and to evaluate its value in predicting the risk of RILI.

Methods: 120 patients with advanced non-small cell lung cancer diagnosed in Jiaozhou Central Hospital of Qingdao City in the past three years and received chest conformal (intensity modulated) radiation therapy were selected. Before radiotherapy, irradiation of 45-50 Gy, and 1 month after radiotherapy, the patients were tested for lung function. The evaluation of radiation lung injury was based on the RTOG acute radiation lung injury classification standard, and the observation end point was ≥2 grade RILI.

Results: There are 34 patients with ≥2 grade RILI among all enrolled patients, including 23 cases of grade 2 and 11 cases of grade 3. The difference between FVC, FEV1, FEV1 / FVC, DLCO, V5, V10, V15 before radiotherapy, 45-50 Gy, and 1 month after radiotherapy were statistically significant (P <0.05). The lung function, V5, V10, and V15 before radiotherapy were related factors for RILI (P <0.05). And the risk of RILI was 1.855 times that of patients with higher FEV1 / FVC before radiation therapy (OR = 1.855 (1.199-1.946)), patients with V10 ≥50% were 3.673 times higher than patients with V10 <50% (OR = 3.673(1.548-7.582)).

Conclusions: V10≥50% and FEV1 / FVC are high-risk factors for RILI before radiotherapy, which has certain value in predicting the risk of RILI.

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放疗前后 DVH 参数和肺功能变化与放射性肺损伤（RILI）发生之间的相关性。

目的方法：选取近三年在青岛市胶州市中心医院确诊并接受胸部适形（调强）放疗的120例晚期非小细胞肺癌患者为研究对象。在放疗前、45-50 Gy照射和放疗后1个月，对患者进行肺功能检测。根据RTOG急性放射性肺损伤分级标准对放射性肺损伤进行评估，观察终点为≥2级RILI：结果：在所有入组患者中，≥2级RILI的患者有34例，其中2级23例，3级11例。V10≥50%和FEV1/FVC是放疗前RILI的高危因素，对预测RILI风险有一定价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.