Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.

IF 3 4区医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2021-09-08 eCollection Date: 2021-01-01 DOI:10.1155/2021/3741104

Dan Lv, Yangpan Ou, Yuhua Wang, Jidong Ma, Chuang Zhan, Ru Yang, Yunhui Chen, Tinghuizi Shang, Cuicui Jia, Lei Sun, Guangfeng Zhang, Zhenghai Sun, Jinyang Li, Xiaoping Wang, Wenbin Guo, Ping Li

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引用次数: 7

Abstract

Background: Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear.

Methods: A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier.

Results: Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%.

Conclusion: Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.

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无药物强迫症患者休息时功能连接强度的改变。

背景:以往的研究利用度方法对强迫症患者的全脑功能连接体进行了探索。然而，是否改变度值可以用来区分强迫症和健康对照(hc)仍不清楚。方法:对40例未服药的强迫症患者和38例hc患者进行静息状态功能磁共振成像(rs-fMRI)扫描。采用度法和支持向量机分类器对数据进行分析。结果:强迫症患者左侧丘脑和左侧小脑一号脚度值升高，左侧背外侧前额叶皮层、右侧楔前叶和左侧中央后回度值降低。支持向量机分类分析表明，左侧丘脑度升高值为强迫症的标志，可接受准确率为88.46%，敏感性为87.50%，特异性为89.47%。结论:皮层-纹状体-丘脑-皮层(CSTC)回路内外度值的改变可能参与了强迫症的病理生理。左丘脑度值升高可作为未来强迫症理解分类的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity NEUROSCIENCES-

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.