Photodynamic Therapy for Infectious Keratitis.

IF 0.9 Q4 OPHTHALMOLOGY Current Ophthalmology Reports Pub Date : 2020-12-01 Epub Date: 2020-09-12 DOI:10.1007/s40135-020-00252-y

Diego Altamirano, Jaime Martinez, Katherine D Leviste, Jean Marie Parel, Guillermo Amescua

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引用次数: 6

Abstract

Infectious keratitis is a sight-threatening microbial infection. The prevalence of antimicrobial resistance in cases of infectious keratitis has increased the demand for fortified compounded antimicrobial drops. Even with proper medical management, severe cases of infectious keratitis can further evolve into corneal perforation, requiring surgical intervention in the form of keratoplasty to control the infectious process. Due to the invasive nature of the procedure and the shortage of available donor tissue around the world, alternative treatments are needed for the management of progressive infectious keratitis. In ophthalmology, photodynamic therapy (PDT) has been used for numerous applications. PDT with Rose Bengal as a photosensitizer combined with green light optical irradiation (RB-PDAT) is a novel treatment with dual purpose: to arrest the infection from progressing and strengthen the collagen of the cornea. RB-PDAT may be considered as an adjunct therapy in severe cases of infectious keratitis to minimize the need for a therapeutic keratoplasty.

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感染性角膜炎的光动力治疗。

感染性角膜炎是一种威胁视力的微生物感染。感染性角膜炎病例中抗菌素耐药性的流行增加了对强化复合抗菌素滴剂的需求。即使有适当的医疗管理，严重的感染性角膜炎病例也可能进一步发展为角膜穿孔，需要角膜移植术的手术干预来控制感染过程。由于手术的侵入性和世界各地可用供体组织的短缺，需要其他治疗方法来管理进行性感染性角膜炎。在眼科，光动力疗法(PDT)已被用于许多应用。以玫瑰花为光敏剂的PDT联合绿光光照射(RB-PDAT)是一种具有双重目的的新型治疗方法:阻止感染的进展并加强角膜的胶原蛋白。RB-PDAT可作为严重感染性角膜炎病例的辅助治疗，以尽量减少治疗性角膜移植术的需要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Ophthalmology Reports Medicine-Ophthalmology

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most significant recent developments in the field of ophthalmology. By providing clear, insightful, balanced contributions, the journal intends to serve those who diagnose, treat, manage, and prevent ocular conditions and diseases. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include age-related macular degeneration; diabetic retinopathy; dry eye syndrome; glaucoma; pediatric ophthalmology; ocular infections; refractive surgery; and stem cell therapy.