Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2021-09-20 DOI:10.5603/GP.a2021.0081

Jian-Qing Wang, Jia-Miao Zhang, Bin Qian

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Abstract

Objectives: This study aimed at assessing the adverse outcomes of pregnancy in women with endometriosis.

Material and methods: The Cochrane, Embase and PubMed databases were searched for identifying the required studies published before June 2019. Meta-analyses of relative risk (RR) were performed under the random-effects model to estimate the risk of selected adverse outcomes of pregnancy in females with endometriosis.

Results: Twenty-eight studies (53,141 women with and 2,355,923 women without endometriosis data) were selected for meta-analysis. Endometriosis bearing females had a significantly higher risk placenta previa (RR 3.92 [95% CI 2.48-6.20]), miscarriage (RR 1.31 [95% CI 1.06-1.61), gestational hypertension (RR 1.30 [95% CI 1.02-1.65]), cesarean section (RR 1.48 [95% CI 1.33-1.65]) and preeclampsia (RR 1.18 [95% CI 1.09-1.28]). The incidence of placental abruption was not statistically significant between the groups (RR 3.62 [95% CI [0.99-13.28]).

Conclusions: Women suffering from endometriosis are at higher risks of miscarriage, preterm birth, gestational hypertension, placenta previa, cesarean section, and preeclampsia.

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子宫内膜异位症妇女的不良妊娠结局：系统回顾和荟萃分析。

研究目的本研究旨在评估子宫内膜异位症女性的不良妊娠结局：对Cochrane、Embase和PubMed数据库进行检索，以确定2019年6月之前发表的所需研究。在随机效应模型下进行相对风险（RR）元分析，以估计子宫内膜异位症女性妊娠不良结局的风险：荟萃分析选取了 28 项研究（53 141 名患有子宫内膜异位症的女性和 2 355 923 名未患有子宫内膜异位症的女性）。患有子宫内膜异位症的女性发生前置胎盘（RR 3.92 [95% CI 2.48-6.20]）、流产（RR 1.31 [95% CI 1.06-1.61]）、妊娠高血压（RR 1.30 [95% CI 1.02-1.65]）、剖宫产（RR 1.48 [95% CI 1.33-1.65]）和子痫前期（RR 1.18 [95% CI 1.09-1.28]）的风险明显更高。胎盘早剥的发生率在各组之间没有统计学意义（RR 3.62 [95% CI [0.99-13.28]）：结论：患有子宫内膜异位症的妇女流产、早产、妊娠高血压、前置胎盘、剖宫产和子痫前期的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.