The impact of growth hormone replacement therapy on adipokines, but not upon ghrelin.

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-12-01 Epub Date: 2021-09-21 DOI:10.23736/S2724-6507.21.03588-0
Alina D Belceanu, Ștefana C Bîlha, Carmen Vulpoi, Dumitru D Brănișteanu
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引用次数: 2

Abstract

Background: Besides growth acceleration, growth hormone (GH) therapy of GH deficient (GHD) children improves body composition by decreasing body fat. This effect is due to GH interaction with lipid and carbohydrate metabolism, possibly also mediated by adipokines secreted by adipose tissue, and ghrelin. This study aimed to assess the impact of one-year GH replacement therapy on the metabolic profile, adipokines, and acylated/unacylated ghrelin of prepubertal children with GHD.

Methods: Prospective observational study of 42 non-obese, prepubertal children with GHD followed up for twelve months. Mean lipid, carbohydrate, adipokine profiles, acylated/unacylated ghrelin, and body composition data before therapy onset were compared with measurements obtained after 6 and 12 months of GH therapy.

Results: Total body fat content and body fat percentage decreased significantly, while the lipid profile improved over the study period in the 42 GHD children with a mean age of 9.2±2.6 years. The levels of leptin and unacylated ghrelin decreased significantly, whereas adiponectin and acylated ghrelin values increased after GH therapy. In regression analysis models, GH treatment (reflected by increased absolute values or standard deviations of IGF1) influences the variation of leptin and adiponectin, but not ghrelin, independently of body composition - lean or fat mass.

Conclusions: GH replacement therapy improves body composition, lipid, and adipokine profile in GHD children. Also, GH replacement therapy directly impacts leptin and adiponectin concentrations, independently of body composition. Further research is needed to identify the molecular mechanisms and metabolic pathways by which the GH/IGF1 axis influences adipokines secretion.

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生长激素替代疗法对脂肪因子有影响,但对胃泌素没有影响。
背景:生长激素缺乏症(GHD)儿童接受生长激素(GH)治疗后,除了能加速生长外,还能通过减少体内脂肪来改善身体组成。这种作用是由于生长激素与脂质和碳水化合物代谢的相互作用,也可能是由脂肪组织分泌的脂肪因子和胃泌素介导的。本研究旨在评估为期一年的 GH 替代治疗对青春期前 GHD 儿童的代谢概况、脂肪因子和酰化/非酰化胃泌素的影响:对 42 名非肥胖的青春期前 GHD 儿童进行为期 12 个月的前瞻性观察研究。将开始治疗前的平均血脂、碳水化合物、脂肪因子概况、酰化/非酰化胃泌素和身体成分数据与GH治疗6个月和12个月后的测量结果进行比较:结果:42名平均年龄为9.2±2.6岁的GHD患儿的总脂肪含量和体脂率显著下降,而血脂状况在研究期间有所改善。在接受 GH 治疗后,瘦素和非酰化胃泌素的水平明显下降,而脂肪连通素和酰化胃泌素的水平则有所上升。在回归分析模型中,GH治疗(反映为IGF1绝对值或标准偏差的增加)影响瘦素和脂肪连通素的变化,但不影响胃泌素的变化,与身体组成(瘦肉或脂肪)无关:结论:GH替代疗法可改善GHD儿童的身体组成、血脂和脂肪因子状况。结论:GH替代疗法可改善GHD儿童的身体成分、血脂和脂肪因子状况。此外,GH替代疗法可直接影响瘦素和脂肪连接蛋白的浓度,而与身体成分无关。要确定 GH/IGF1 轴影响脂肪因子分泌的分子机制和代谢途径,还需要进一步的研究。
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146
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