First fluconazole-resistant Candida auris isolated from fungal otitis in Iran.

Q3 Medicine Current Medical Mycology Pub Date : 2021-03-01 DOI:10.18502/cmm.7.1.6243

Mojtaba Taghizadeh Armaki, Saeid Mahdavi Omran, Keyvan Kiakojuri, Shaghayegh Khojasteh, Jalal Jafarzadeh, Mahin Tavakoli, Hamid Badali, Iman Haghani, Tahereh Shokohi, Mohammad Taghi Hedayati, Mahdi Abastabar

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引用次数: 15

Abstract

Background and purpose: Candida auris, as a new characterized pathogenic yeast, has attracted remarkable attention in the recent decade due to its rapid global emergence and multidrug resistance traits. This unique species is able to cause nosocomial outbreaks and tolerate adverse conditions; however, it has been mostly misidentified by conventional methods.

Case report: This report aimed to describe the first fluconazole-resistant case of C. auris otitis in an immunocompetent patient in Iran. The isolate showed minimum inhibitory concentration of ≥ 32 μg/ml for fluconazole; however, the patient was treated with topical clotrimazole and miconazole with no recurrence.

Conclusion: This was the second strain of C. auris isolated from otitis in Iran which was fluconazole-resistant, unlike the first Iranian isolate.

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伊朗首次从真菌性中耳炎中分离出耐氟康唑耳念珠菌。

背景与目的:耳念珠菌作为一种新型的病原酵母菌，由于其在全球范围内的迅速出现和多药耐药的特点，近十年来引起了人们的广泛关注。这种独特的物种能够引起医院暴发并耐受不利条件;然而，传统方法大多对其进行了错误识别。病例报告:本报告旨在描述伊朗一名免疫功能正常的患者中第一例氟康唑耐药的耳原性耳炎病例。分离物对氟康唑的最低抑菌浓度≥32 μg/ml;然而，患者局部应用克霉唑和咪康唑治疗，无复发。结论:这是从伊朗中耳炎中分离到的第二株对氟康唑耐药的耳念珠菌，与第一株不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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