Low-intensity extracorporeal shockwave therapy for erectile dysfunction.

IF 1.3 Q3 UROLOGY & NEPHROLOGY Arab Journal of Urology Pub Date : 2021-07-05 eCollection Date: 2021-01-01 DOI:10.1080/2090598X.2021.1948158

Onder Canguven, Kareim Khalafalla, Abdulla Al Ansari

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Abstract

Objectives: To review the current evidence of clinical effectiveness of low-intensity extracorporeal shockwave therapy (LI-ESWT) treatment for erectile dysfunction (ED).

Methods: A selective database search using Medical Subject Headings (MeSH) terms 'low intensity extracorporeal shock wave therapy' and 'erectile dysfunction' was conducted in accordance with the Preferred Reporting Items for Systemic Reviews and Meta Analyses (PRISMA) guidelines to review the effectiveness of LI-ESWT for ED. We performed a systematic search of publications using the PubMed and Web of Science databases (January 2010-December 2020) for prospective randomised clinical trials (RCTs). The success rate of LI-ESWT associated with ED were recorded and analysed.

Results: A total of 106 articles were reviewed after searching for the keywords. Overall, 11 RCTs were included in this systematic review. A total of 920 male patients were treated in 11 RCTs. The patients' ages ranged from 18 to 80 years and they had ≥3 months of ED symptoms. Vasculogenic and neurogenic causes were addressed in 81% and 19% of patients, respectively. Of the 920 patients, 348 patients had a statistically significant improvement in their erectile function after LI-ESWT; however, 572 did not have a statistically significant improvement.

Conclusions: The present review found that LI-ESWT has a role in ED treatment in laboratory studies, but its role in human clinical trials is still controversial. Further good quality studies need to be conducted to properly assess its true potential in ED treatment.

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治疗勃起功能障碍的低强度体外冲击波疗法。

目的回顾低强度体外冲击波疗法（LI-ESWT）治疗勃起功能障碍（ED）临床有效性的现有证据：根据《系统综述和元分析首选报告项目》（Preferred Reporting Items for Systemic Reviews and Meta Analyses，PRISMA）指南，使用医学主题词表（Medical Subject Headings，MeSH）术语 "低强度体外冲击波疗法 "和 "勃起功能障碍 "进行了选择性数据库检索，以回顾低强度体外冲击波疗法治疗 ED 的有效性。我们使用 PubMed 和 Web of Science 数据库（2010 年 1 月至 2020 年 12 月）对前瞻性随机临床试验 (RCT) 的出版物进行了系统性检索。我们记录并分析了LI-ESWT治疗ED的成功率：结果：搜索关键词后，共查阅了 106 篇文章。结果：通过搜索关键词，共查阅了 106 篇文章。在 11 项研究中，共有 920 名男性患者接受了治疗。患者年龄从18岁到80岁不等，出现ED症状≥3个月。分别有 81% 和 19% 的患者接受了血管性和神经源性治疗。在920名患者中，348名患者在接受LI-ESWT治疗后，勃起功能有了统计学意义上的显著改善；然而，572名患者的勃起功能没有得到统计学意义上的显著改善：本综述发现，LI-ESWT 在实验室研究中具有治疗 ED 的作用，但在人体临床试验中的作用仍存在争议。要正确评估其在 ED 治疗中的真正潜力，还需要开展更多高质量的研究。

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来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

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0.00%

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期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.