Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal.

Q3 Medicine Experimental oncology Pub Date : 2021-09-01 DOI:10.32471/exp-oncology.2312-8852.vol-43-no-3.16584

V F Konovalenko, N K Ternovyi, E V Tuz, V V Protsenko, E O Solonitsyn, Audai Abudayeh, O V Drobotun, N V Ulianchych

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引用次数: 3

Abstract

Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering.

Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition.

Materials and methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks. Morphological studies were carried out using light and electron microscopy.

Results: In the dynamics of observation at 2, 4 and 8 weeks, a gradual arrangement of osteoclasts and osteoblasts on the surface of HAP-TCP was recorded, which indicates its high biocompatibility with bone tissue. During the experiment, the processes of resorption of implants, mineralization, proliferation of cellular elements of collagen and osteogenesis (osteoblasts and osteoclasts) and the formation of mature bone tissue were recorded.

Conclusions: Experimental studies of plastic bone defects proved the presence of the osteoinductive and osteointegrative effect of HAP-TCP composition, which contributes to a more dynamic uncomplicated course of reparative osteogenesis.

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羟基磷灰石-磷酸三钙生物陶瓷替代肿瘤切除后骨缺损的实验证实。

背景:近年来，羟基磷灰石(HAP)和磷酸三钙(TCP)生物活性陶瓷已成为骨工程中首选的种植体。目的:研究用原HAP-TCP组合物充填干骺端缺损的骨再生情况。材料与方法:实验采用自交系大鼠，观察期分别为2、4、8周。形态学研究采用光镜和电镜进行。结果:在2周、4周和8周的动态观察中，记录到HAP-TCP表面的破骨细胞和成骨细胞逐渐排列，表明其与骨组织具有较高的生物相容性。实验过程中记录了种植体的吸收、矿化、胶原细胞成分和成骨细胞(成骨细胞和破骨细胞)的增殖以及成熟骨组织的形成过程。结论:塑性骨缺损的实验研究证实了HAP-TCP组合物的成骨诱导和骨整合作用，有助于更动态、更简单的修复成骨过程。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

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0.00%

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期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.