The relationship between thyroid function and ovarian reserve: a prospective cross-sectional study.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Thyroid Research Pub Date : 2021-10-01 DOI:10.1186/s13044-021-00112-2
Roya Kabodmehri, Seyedeh Hajar Sharami, Ziba Zahiri Sorouri, Nasrin Ghanami Gashti, Forozan Milani, Zeinab Chaypaz, Maryam Ghalandari
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引用次数: 9

Abstract

Background: Thyroid dysfunction can affect fertility and miscarriage risk by affecting the process of follicular growth, embryo development, implantation, and placental formation. It has been suggested that thyroid disorders are associated with ovarian reserve by affecting the follicular process. The aim of the present study was to investigate the relationship between thyroid hormone levels and ovarian reserve.

Methods: Three hundred fourteen women with infertility due to various etiologies were enrolled in this study (172 individuals with Anti-Mullerian hormone (AMH) level ≥ 1.1 ng/ml and 142 individuals with AMH < 1.1 ng/ml). Serum levels of follicle-stimulating hormone (FSH), estradiol (E2) on day 2-4 of menstrual cycles, AMH, Thyroid-stimulating hormone (TSH), and thyroxine (free T4) were evaluated.

Results: In participants with age over 35 years, median TSH level in women with AMH < 1.1 ng/ml was significantly higher than those with AMH ≥1.1 ng/ml (P-value =0.037). There was no significant difference in body mass index (BMI) in patients with age older than 35 years and younger than 35 years sub-groups based on AMH level (P-value = 0.102, and P-value = 0.909 respectively). With one unit increase in TSH level, the odds of having AMH < 1.1 ng/ml increases by 1.25 times or by 25% (P-value =0.017). Receiver operator characteristic (ROC) curve analysis showed a TSH cut-off point of 1.465 mIU/L in participants over 35 years in identifying decreased AMH level.

Conclusion: Our study supports the relationship between TSH level and ovarian reserve so that with an increase in TSH from a certain level is associated with a decrease in ovarian function.

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甲状腺功能与卵巢储备的关系:一项前瞻性横断面研究。
背景:甲状腺功能障碍可通过影响卵泡生长、胚胎发育、着床和胎盘形成过程而影响生育能力和流产风险。有研究表明,甲状腺疾病通过影响卵泡过程与卵巢储备有关。本研究的目的是探讨甲状腺激素水平与卵巢储备的关系。方法:本研究纳入了314例因各种原因导致的不孕症妇女,其中抗苗勒管激素(AMH)水平≥1.1 ng/ml的有172例,AMH的有142例。结果:在年龄大于35岁的参与者中,AMH妇女的中位TSH水平。结论:我们的研究支持TSH水平与卵巢储备之间的关系,TSH从一定水平升高与卵巢功能下降有关。
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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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