The relevance analysis of GSTP1 rs1695 and lung cancer in the Chinese Han population.

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY International Journal of Biological Markers Pub Date : 2021-09-01 Epub Date: 2021-10-01 DOI:10.1177/17246008211039236

Jiang Xiao, Yulu Wang, Zhimin Wang, Yao Zhang, Yutao Li, Chang Xu, Man Xiao, Haijian Wang, Shicheng Guo, Li Jin, Jiucun Wang, Yang Bao, Yan Shang, Junjie Wu

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引用次数: 3

Abstract

Background: This study explored the relevance between rs1695 and susceptibility to the lung cancer in the Chinese Han population. Stratification analysis was conducted on the basis of age, gender, smoking status, tumor-related family history, and pathological type to observe relations between rs1695 and susceptibility to lung cancer in the subgroups.

Methods: A case-control study was performed with 974 lung cancer patients who were pathologically diagnosed and 1005 healthy cases based on physical examination to analyze the association between rs1695 and the risk of lung cancer.

Results: The frequencies of the AA, GA, and GG genotypes of rs1695 were 68.4%, 28.7%, and 2.9% in cases and 64.8%, 30.8%, and 4.2% in controls, respectively. After adjustment for age, gender, smoking status, and family history, it appears that the rs1695 G allele decreases the risk of lung cancer (OR = 0.811, 95% CI 0.684-0.961, P = 0.016). Moreover, compared with the AA genotype, the GA + GG genotype decreased lung cancer susceptibility (OR = 0.808, 95% CI 0.663-0.985, P = 0.035) and the GG genotype (OR = 0.591, 95% CI 0.347-0.988, P = 0.048). In a stratified analysis, the risk of lung cancer in the G allele carriers decreased among the males, patients without a tumor-related family history, and patients with lung adenocarcinoma, especially in smokers.

Conclusion: The polymorphism of locus rs1695 is related to the risk of lung cancer and is expected to be a target for the prediction of lung cancer.

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GSTP1 rs1695基因与中国汉族人群肺癌的相关性分析

背景:本研究探讨rs1695与中国汉族人群肺癌易感性的相关性。根据年龄、性别、吸烟情况、肿瘤相关家族史、病理类型进行分层分析，观察各亚组rs1695与肺癌易感性的关系。方法:采用病例对照研究方法，选取974例经病理诊断的肺癌患者和1005例体检的健康患者，分析rs1695与肺癌发病风险的相关性。结果:rs1695 AA、GA、GG基因型在病例中分别为68.4%、28.7%、2.9%，在对照组中分别为64.8%、30.8%、4.2%。在调整了年龄、性别、吸烟状况和家族史后，rs1695 G等位基因降低了肺癌的风险(OR = 0.811, 95% CI 0.684-0.961, P = 0.016)。与AA基因型相比，GA + GG基因型降低肺癌易感性(OR = 0.808, 95% CI 0.663 ~ 0.985, P = 0.035)， GG基因型降低肺癌易感性(OR = 0.591, 95% CI 0.347 ~ 0.988, P = 0.048)。在一项分层分析中，G等位基因携带者在男性、无肿瘤相关家族史的患者和肺腺癌患者(尤其是吸烟者)中患肺癌的风险降低。结论:rs1695位点多态性与肺癌发生风险相关，有望成为肺癌预测的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Markers 医学-生物工程与应用微生物

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.