Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-10-01
Soomin Ahn, Hyeona Bae, Jihu Kim, Suhee Kim, Jinho Park, Sang-Ki Kim, Dong-In Jung, DoHyeon Yu
{"title":"Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.","authors":"Soomin Ahn,&nbsp;Hyeona Bae,&nbsp;Jihu Kim,&nbsp;Suhee Kim,&nbsp;Jinho Park,&nbsp;Sang-Ki Kim,&nbsp;Dong-In Jung,&nbsp;DoHyeon Yu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to identify potential biomarkers of canine pyometra and their correlations with clinical parameters. First, 90 dogs with pyometra and 26 healthy female dogs were compared. Then, paired samples (before and after ovariohysterectomy) from 22 dogs with pyometra and 9 healthy controls from the initial cohort were compared. Concentrations of acute inflammatory proteins, C-reactive protein (CRP) and serum amyloid A (SAA), and cell-free DNA (cfDNA), were significantly higher in dogs with pyometra than in clinically healthy dogs. Cell-free DNA was the most sensitive biomarker for systemic inflammation, based on the receiver operating characteristic curve analysis (area under the curve = 0.959). In addition, cfDNA and CRP were significantly associated with inflammation and organ injury-related clinical parameters. Following the surgical removal of the inflamed uterus, interleukin-6 (IL-6), high-mobility group box 1 (HMGB1), and procalcitonin (PCT) significantly decreased, whereas changes in CRP, SAA, and cfDNA were not significant. These findings indicate that cfDNA, CRP, and SAA are potential clinical biomarkers of systemic inflammation in dogs with pyometra and PCT, IL-6, and HMGB1 are potential biomarkers of clinical recovery.</p>","PeriodicalId":9550,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451705/pdf/cjvr_04_271.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","FirstCategoryId":"97","ListUrlMain":"","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Veterinary","Score":null,"Total":0}
引用次数: 0

Abstract

This study aimed to identify potential biomarkers of canine pyometra and their correlations with clinical parameters. First, 90 dogs with pyometra and 26 healthy female dogs were compared. Then, paired samples (before and after ovariohysterectomy) from 22 dogs with pyometra and 9 healthy controls from the initial cohort were compared. Concentrations of acute inflammatory proteins, C-reactive protein (CRP) and serum amyloid A (SAA), and cell-free DNA (cfDNA), were significantly higher in dogs with pyometra than in clinically healthy dogs. Cell-free DNA was the most sensitive biomarker for systemic inflammation, based on the receiver operating characteristic curve analysis (area under the curve = 0.959). In addition, cfDNA and CRP were significantly associated with inflammation and organ injury-related clinical parameters. Following the surgical removal of the inflamed uterus, interleukin-6 (IL-6), high-mobility group box 1 (HMGB1), and procalcitonin (PCT) significantly decreased, whereas changes in CRP, SAA, and cfDNA were not significant. These findings indicate that cfDNA, CRP, and SAA are potential clinical biomarkers of systemic inflammation in dogs with pyometra and PCT, IL-6, and HMGB1 are potential biomarkers of clinical recovery.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
子宫积脓犬卵巢子宫切除术前后临床及炎症参数的比较。
本研究旨在确定犬脓脓症的潜在生物标志物及其与临床参数的相关性。首先,将90只脓膜增生犬与26只健康母犬进行比较。然后,对22只脓膜瘤犬和9只健康对照犬的配对样本(卵巢子宫切除术前后)进行比较。脓脓狗的急性炎症蛋白、c反应蛋白(CRP)、血清淀粉样蛋白A (SAA)和无细胞DNA (cfDNA)浓度显著高于临床健康狗。根据受试者工作特征曲线分析(曲线下面积= 0.959),无细胞DNA是全身性炎症最敏感的生物标志物。此外,cfDNA和CRP与炎症和器官损伤相关的临床参数显著相关。手术切除发炎子宫后,白细胞介素-6 (IL-6)、高迁移率组盒1 (HMGB1)和降钙素原(PCT)显著降低,而CRP、SAA和cfDNA的变化不显著。这些发现表明cfDNA、CRP和SAA是脓脓症犬全身炎症的潜在临床生物标志物,PCT、IL-6和HMGB1是临床恢复的潜在生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
期刊最新文献
Changing of the guard: Exits from and entrances to the Canadian Veterinary Medical Association Editorial Committee. Greetings from the new CJVR Editor. Iliopsoas strain demographics, concurrent injuries, and grade determined by musculoskeletal ultrasound in 72 agility dogs. Comparison of two ratios of xylazine:ketamine for the anesthesia of free-ranging North American beavers (Castor canadensis) in a remote setting. Relationship between the degree of stifle flexion and the proximal patellofemoral angle in the sagittal plane: A radiographic study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1