C-kit, flt-3, PDGFR-β, and VEGFR2 expression in canine adrenal tumors and correlation with outcome following adrenalectomy.

IF 1.1 4区 农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-10-01
Kayla Harding, Carlos H De Mello Souza, Keijiro Shiomitsu, Elizabeth Maxwell, Judit Bertran
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Abstract

The objective of this retrospective study was to evaluate the expression of receptor tyrosine kinases (RTKs) in canine adrenal tumors and correlate this expression with features of tumor aggressiveness and survival in dogs undergoing adrenalectomy. Forty-three canine adrenal tumors were evaluated for expression of c-kit, fms-like tyrosine kinase 3 (flt-3), platelet-derived growth factor receptor-β (PDGFR-β), and vascular endothelial growth factor receptor 2 (VEGFR2) using immunohistochemistry. Tumor RTK staining characteristics were compared to normal adrenals. Medical records were reviewed for data regarding patient outcome and tumor characteristics. Expression of c-kit, flt-3, PDGFR-β, and VEGFR2 was detected in 26.9%, 92.3%, 96.2%, and 61.5% of cortical tumors and 0%, 63.2%, 47.4%, and 15.8% of pheochromocytomas, respectively. Expression of RTKs was not significantly increased when compared to normal adrenals and did not correlate with survival after adrenalectomy. Receptor tyrosine kinases are not overexpressed in canine adrenal tumors compared to normal adrenal tissue. Therapeutic inhibition of these receptors may still represent an effective approach in cases where receptor activation is present.

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C-kit、flt-3、PDGFR-β和VEGFR2在犬肾上腺肿瘤中的表达及其与肾上腺切除术后预后的相关性
本回顾性研究的目的是评估受体酪氨酸激酶(RTKs)在犬肾上腺肿瘤中的表达,并将其与肾上腺切除术后犬肿瘤侵袭性和生存率的特征联系起来。采用免疫组织化学方法对43例犬肾上腺肿瘤进行c-kit、fms样酪氨酸激酶3 (flt-3)、血小板衍生生长因子受体-β (PDGFR-β)和血管内皮生长因子受体2 (VEGFR2)的表达评估。比较肿瘤与正常肾上腺的RTK染色特征。回顾了有关患者预后和肿瘤特征的医疗记录。c-kit、flt-3、PDGFR-β和VEGFR2在皮质肿瘤中的表达分别为26.9%、92.3%、96.2%和61.5%,在嗜铬细胞瘤中的表达分别为0%、63.2%、47.4%和15.8%。与正常肾上腺相比,RTKs的表达没有显著增加,并且与肾上腺切除术后的生存无关。与正常肾上腺组织相比,受体酪氨酸激酶在犬肾上腺肿瘤中不过度表达。在存在受体激活的情况下,治疗性抑制这些受体可能仍然是一种有效的方法。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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