H Rothe, A Gaber, B Dittrich, M Nagel, M Tuffaha, B Hoschke
{"title":"[Epithelioid angiomyolipoma of the kidney after successfully treated malignant melanoma].","authors":"H Rothe, A Gaber, B Dittrich, M Nagel, M Tuffaha, B Hoschke","doi":"10.1007/s00120-021-01662-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Therapy of epitheloid angiomyolipomas (eAML) may be challenging, since unlike classical angiomyolipomas this rare subclass of benign mesenchymal angiomyolipomas may present with lymph node metastases, local recurrent disease, and/or systemic metastatic disease in up to 30% of cases.</p><p><strong>Objectives: </strong>We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.</p><p><strong>Materials and methods: </strong>Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.</p><p><strong>Results: </strong>A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.</p><p><strong>Conclusion: </strong>The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.</p>","PeriodicalId":11123,"journal":{"name":"Der Urologe. Ausg. A","volume":" ","pages":"183-186"},"PeriodicalIF":0.0000,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831349/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Der Urologe. Ausg. A","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00120-021-01662-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/10/4 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Therapy of epitheloid angiomyolipomas (eAML) may be challenging, since unlike classical angiomyolipomas this rare subclass of benign mesenchymal angiomyolipomas may present with lymph node metastases, local recurrent disease, and/or systemic metastatic disease in up to 30% of cases.
Objectives: We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.
Materials and methods: Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.
Results: A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.
Conclusion: The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
