Minh Tam Le, Hiep Tuyet Thi Nguyen, Hong Nhan Thi Dang, Thai Thanh Thi Nguyen, Trung Van Nguyen, Quoc Huy Vu Nguyen
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引用次数: 1
Abstract
Background: A direct association between metabolic syndrome (MetS) and sperm production/function has been proposed. In this cross-sectional study, we aimed to determine the impact of MetS on sperm survival. Men from infertile couples treated at Hue University Hospital, Vietnam, were enrolled in this study, which spanned the October 2018 to October 2020 period. The general characteristics of the patients, including body mass index (BMI), waist-to-hip ratio (WHR), the levels of different biochemicals, and semen parameters were determined, and sperm survival tests (SSTs) were performed. The modified National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III for the Asian population was used for MetS diagnosis.
Results: Men with an abnormal waist circumference (≥ 90 cm) showed a higher rate of abnormal SST results (30.1% vs. 16.7%, p = 0.012). The frequency of abnormal SST results in patients with MetS (72.3%) was significantly higher than that in individuals without MetS (53.4%) (p = 0.02). Furthermore, the percentage of abnormal SST results in patients with MetS and with BMI ≥ 23 was significantly higher than those in individuals without MetS (77.1% vs. 55.2%, p = 0.03). Weak negative correlations were also observed between the patients' age and the SST results.
Conclusion: Sperm viability was lower in men with MetS. We also observed that age and BMI were independent factors associated with abnormal SST.
背景:代谢综合征(MetS)与精子产生/功能之间存在直接关联。在这项横断面研究中，我们旨在确定MetS对精子存活的影响。在越南顺化大学医院接受治疗的不育夫妇的男性参加了这项研究，研究时间从2018年10月到2020年10月。测定患者的一般特征，包括身体质量指数(BMI)、腰臀比(WHR)、不同生化物质水平和精液参数，并进行精子存活试验(SSTs)。修订后的国家胆固醇教育计划(NCEP)成人治疗小组(ATP) III用于亚洲人群的MetS诊断。结果:腰围≥90 cm的男性SST异常发生率较高(30.1% vs. 16.7%， p = 0.012)。MetS患者SST结果异常的频率(72.3%)显著高于无MetS患者(53.4%)(p = 0.02)。此外，BMI≥23的MetS患者的SST结果异常百分比显著高于无MetS患者(77.1% vs. 55.2%， p = 0.03)。患者年龄与SST结果之间也存在弱负相关。结论:met患者精子活力较低。我们还观察到年龄和BMI是与异常海温相关的独立因素。
期刊介绍：
Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.
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