Potential Protective Effect of Spirulina Platensis on Sodium Arsenite Induced Cardiotoxicity in Male Rats.

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2022-04-03 Epub Date: 2021-10-06 DOI:10.1080/21688370.2021.1983330

Amal Albtoosh, Fardous Karawya, Wesam Al-Naymat, Aiman Al-Qaitat

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Abstract

Background: Sodium arsenite is a dangerous bio-accumulative poison affecting a large number of people as well as animals throughout the world. It is used clinically in the treatment of certain medical conditions, but due to its harmful damage to different tissues and mainly the cardiotoxicity, its medical application is limited.

Aim: This study was conducted to investigate the protective effects of spirulina on cardiotoxicity induced by sodium arsenite biochemically and histologically.

Methods: 30 young adult male albino rats were randomly equally divided into three groups 10 animals each. Group I (control), Group II Arsenic intoxicated (10 mg/kg/day/ 4 weeks), Group III spirulina protected animals (concomitant sodium arsenite 10 mg/kg/day/ 4 weeks and spirulina 200 mg/kg/day/ 4 weeks).

Results: It was evident from the study that arsenic exposure exerted a significant increase in cardiac enzyme levels, serum creatine kinase MB (CKMB) and troponin. Concomitant treatment with spirulina is considerably recovered their serum levels. Histological alterations associated with arsenite treated animals are significantly decreased after using spirulina.

Conclusions: The results of the present study showed that use of spirulina could alleviate the toxic effects on the heart following exposure to arsenic toxicity.

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螺旋藻对亚砷酸钠诱发雄性大鼠心脏毒性的潜在保护作用

背景：亚砷酸钠是一种危险的生物蓄积性毒物，影响着世界各地的许多人和动物。本研究旨在从生化和组织学角度研究螺旋藻对亚砷酸钠诱导的心脏毒性的保护作用。第一组（对照组），第二组砷中毒（10 毫克/千克/天/4 周），第三组螺旋藻保护动物（同时使用亚砷酸钠 10 毫克/千克/天/4 周和螺旋藻 200 毫克/千克/天/4 周）：结果：研究表明，砷暴露会显著增加心肌酶水平、血清肌酸激酶 MB (CKMB) 和肌钙蛋白。同时服用螺旋藻可大大降低其血清水平。使用螺旋藻后，亚砷酸盐处理动物的相关组织学改变明显减少：本研究结果表明，使用螺旋藻可以减轻砷中毒对心脏的毒性影响。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico

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