Microbiota, Prostatitis, and Fertility: Bacterial Diversity as a Possible Health Ally.

IF 1.8 Q3 UROLOGY & NEPHROLOGY Advances in Urology Pub Date : 2021-09-28 eCollection Date: 2021-01-01 DOI:10.1155/2021/1007366
Jenniffer Puerta Suárez, Walter D Cardona Maya
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引用次数: 7

Abstract

Background: In health, microorganisms have been associated with the disease, although the current knowledge shows that the microbiota present in various anatomical sites is associated with multiple benefits.

Objective: This study aimed to evaluate and compare the genitourinary microbiota of chronic prostatitis symptoms patients and fertile men.

Materials and methods: In this preliminary study, ten volunteers have included 5 volunteers with symptoms of chronic prostatitis (prostatitis group) and five fertile volunteers, asymptomatic for urogenital infections (control group) matched by age. Bacterial diversity analysis was performed using the 16S molecular marker to compare the microbiota present in urine and semen samples from chronic prostatitis symptoms and fertile volunteers. Seminal quality, nitric oxide levels, and seminal and serum concentration of proinflammatory cytokines were quantified.

Results: Fertile men present a greater variety of operational taxonomical units-OTUs in semen (67.5%) and urine (17.6%) samples than chronic prostatitis symptoms men. Chronic prostatitis symptoms men presented a higher concentration of IL-12p70 in seminal plasma. No statistically significant differences were observed in conventional and functional seminal parameters. The species diversity in semen samples was similar in healthy men than prostatitis patients, inverted Simpson index median 5.3 (5.0-10.7) vs. 4.5 (2.1-7.8, p=0.1508). Nevertheless, the microbiota present in the semen and urine samples of fertile men presents more OTUs. Less microbial diversity could be associated with chronic prostatitis symptoms. The presence of bacteria in the genitourinary tract is not always associated with the disease. Understanding the factors that affect the microbiota can implement lifestyle habits that prevent chronic prostatitis.

Conclusion: Chronic prostatitis does not seem to affect male fertility; however, studies with a larger sample size are required. Our preliminary results strengthen the potential role; the greater bacterial diversity is a protective factor for chronic prostatitis.

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微生物群、前列腺炎和生育能力:细菌多样性是可能的健康盟友。
背景:在健康方面,微生物与疾病有关,尽管目前的知识表明,存在于不同解剖部位的微生物群与多种益处有关。目的:本研究旨在评价和比较慢性前列腺炎症状患者和育龄男性的泌尿生殖系统微生物群。材料与方法:在本初步研究中,10名志愿者,包括5名有慢性前列腺炎症状的志愿者(前列腺炎组)和5名有生育能力的志愿者,无症状的泌尿生殖系统感染(对照组),按年龄匹配。使用16S分子标记进行细菌多样性分析,比较慢性前列腺炎症状和有生育能力的志愿者尿液和精液样本中的微生物群。量化精液质量、一氧化氮水平、精液和血清促炎细胞因子浓度。结果:与有慢性前列腺炎症状的男性相比,有生育能力的男性在精液(67.5%)和尿液(17.6%)样本中表现出更多的操作分类单位——otus。慢性前列腺炎症状男性精浆中IL-12p70浓度较高。常规和功能性精液参数无统计学差异。健康男性和前列腺炎患者精液样本的物种多样性相似,倒辛普森指数中位数分别为5.3(5.0-10.7)和4.5 (2.1-7.8,p=0.1508)。然而,有生育能力的男性精液和尿液样本中的微生物群呈现出更多的otu。微生物多样性减少可能与慢性前列腺炎症状有关。泌尿生殖系统中细菌的存在并不总是与疾病有关。了解影响微生物群的因素可以实施预防慢性前列腺炎的生活习惯。结论:慢性前列腺炎似乎不影响男性生育能力;然而,研究需要更大的样本量。我们的初步结果加强了潜在的作用;更大的细菌多样性是慢性前列腺炎的保护因素。
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来源期刊
Advances in Urology
Advances in Urology UROLOGY & NEPHROLOGY-
CiteScore
2.90
自引率
0.00%
发文量
17
审稿时长
15 weeks
期刊介绍: Advances in Urology is a peer-reviewed, open access journal that publishes state-of-the-art reviews and original research papers of wide interest in all fields of urology. The journal strives to provide publication of important manuscripts to the widest possible audience worldwide, without the constraints of expensive, hard-to-access, traditional bound journals. Advances in Urology is designed to improve publication access of both well-established urologic scientists and less well-established writers, by allowing interested scientists worldwide to participate fully.
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