Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population.

IF 3.3 4区医学 Q1 PHYSIOLOGY Journal of Physiological Anthropology Pub Date : 2021-10-09 DOI:10.1186/s40101-021-00264-y

Yuji Shimizu, Yuko Nabeshima-Kimura, Shin-Ya Kawashiri, Yuko Noguchi, Shigeki Minami, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida

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引用次数: 2

Abstract

Background: High normal levels of thyroid-stimulating hormone (TSH) have been reported to be associated with chronic kidney disease (CKD) among euthyroid individuals. However, there has been only limited research on the association between TSH and proteinuria, a major risk factor for the progression of renal disease.

Methods: A cross-sectional study of 1595 euthyroid individuals was conducted. All participants were within the normal range for free triiodothyronine (T3), free thyroxine (T4), and TSH. Analyses were stratified by thyroid cyst status to test the hypothesis that the absence of thyroid cysts, an indicator of latent thyroid damage, is associated with declining ability to synthesis thyroid hormone.

Results: For participants with thyroid cysts, a significant inverse association between TSH and proteinuria was observed (adjusted odds ratio (95% confidence intervals) of log-transformed TSH for proteinuria 0.40 (0.18, 0.89)). In participants without thyroid cysts, a significant positive association between those two factors was observed (2.06 (1.09, 3.90)).

Conclusions: Among euthyroid individuals in the general population, being in the normal range of TSH was found to have an ambivalent association with proteinuria. Thyroid cyst status could be an effect modifier for those associations.

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促甲状腺激素(TSH)和蛋白尿与正常甲状腺人群甲状腺囊肿的关系。

背景:据报道，在甲状腺功能正常的个体中，高水平的促甲状腺激素(TSH)与慢性肾脏疾病(CKD)有关。然而，关于TSH与蛋白尿(肾脏疾病进展的主要危险因素)之间关系的研究非常有限。方法:对1595例甲状腺功能正常个体进行横断面研究。所有参与者的游离三碘甲状腺原氨酸(T3)、游离甲状腺素(T4)和TSH均在正常范围内。根据甲状腺囊肿状态对分析进行分层，以验证甲状腺囊肿的缺失(潜在甲状腺损伤的一个指标)与甲状腺激素合成能力下降有关的假设。结果:对于患有甲状腺囊肿的参与者，观察到TSH和蛋白尿之间存在显著的负相关(对数转换TSH与蛋白尿的校正比值比(95%置信区间)为0.40(0.18,0.89))。在没有甲状腺囊肿的参与者中，这两个因素之间的显著正相关被观察到(2.06(1.09,3.90))。结论:在普通人群中甲状腺功能正常的个体中，TSH处于正常范围与蛋白尿存在矛盾关系。甲状腺囊肿状况可能是这些关联的影响调节因素。

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Journal of Physiological Anthropology PHYSIOLOGY-

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6.50%

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期刊介绍： Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment. The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life. Topic areas include, but are not limited to: environmental physiology bio-cultural environment living environment epigenetic adaptation development and growth age and sex differences nutrition and morphology physical fitness and health Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.