Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

IF 2 4区 医学 Q3 HEALTH POLICY & SERVICES Healthcare-The Journal of Delivery Science and Innovation Pub Date : 2021-12-01 DOI:10.1016/j.hjdsi.2021.100581
Camille E. Morgan , Casey A. Rimland , Griffin J. Bell , Min K. Kim , Tanner Hedrick , Ashley Marx , Brian Bramson , Heidi Swygard , Sonia Napravnik , John L. Schmitz , Shannon S. Carson , William A. Fischer , Joseph J. Eron , Cynthia L. Gay , Jonathan B. Parr
{"title":"Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic","authors":"Camille E. Morgan ,&nbsp;Casey A. Rimland ,&nbsp;Griffin J. Bell ,&nbsp;Min K. Kim ,&nbsp;Tanner Hedrick ,&nbsp;Ashley Marx ,&nbsp;Brian Bramson ,&nbsp;Heidi Swygard ,&nbsp;Sonia Napravnik ,&nbsp;John L. Schmitz ,&nbsp;Shannon S. Carson ,&nbsp;William A. Fischer ,&nbsp;Joseph J. Eron ,&nbsp;Cynthia L. Gay ,&nbsp;Jonathan B. Parr","doi":"10.1016/j.hjdsi.2021.100581","DOIUrl":null,"url":null,"abstract":"<div><p>The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty.</p></div>","PeriodicalId":29963,"journal":{"name":"Healthcare-The Journal of Delivery Science and Innovation","volume":"9 4","pages":"Article 100581"},"PeriodicalIF":2.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hjdsi.2021.100581","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Healthcare-The Journal of Delivery Science and Innovation","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213076421000646","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEALTH POLICY & SERVICES","Score":null,"Total":0}
引用次数: 1

Abstract

The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty.

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
快速分析当地数据,以便在COVID-19大流行早期为适应症外用药提供信息
基于小型观察性研究,白细胞介素-6受体拮抗剂托珠单抗在2019冠状病毒病(COVID-19)大流行的早期被广泛使用,这些研究表明对高炎症状态的COVID-19患者有临床益处。为了在缺乏随机临床试验结果的情况下为我们的本地治疗算法提供信息,我们对在我们的学术医疗中心接受tocilizumab治疗的前11名住院的COVID-19患者进行了快速分析。我们报告了他们的早期临床结果,并描述了我们在临床不确定时期组建了一个由不同的学员和利益相关者组成的团队来提取、分析和传播数据的过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
4.90
自引率
0.00%
发文量
37
期刊介绍: HealthCare: The Journal of Delivery Science and Innovation is a quarterly journal. The journal promotes cutting edge research on innovation in healthcare delivery, including improvements in systems, processes, management, and applied information technology. The journal welcomes submissions of original research articles, case studies capturing "policy to practice" or "implementation of best practices", commentaries, and critical reviews of relevant novel programs and products. The scope of the journal includes topics directly related to delivering healthcare, such as: ● Care redesign ● Applied health IT ● Payment innovation ● Managerial innovation ● Quality improvement (QI) research ● New training and education models ● Comparative delivery innovation
期刊最新文献
AI-enabled decision support: The convergence of technology and decision science Corrigendum to "Reading the crystal ball: Primary care implications while awaiting outcomes for multi-cancer early detection tests" [Healthcare 11 (2023) 100705]. The national ambulatory medical care survey (NAMCS) at fifty: Past and future Implementation and adaptation of clinical quality improvement opioid measures Association between patient-reported financial burden and catastrophic health expenditures in cancer survivors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1