Trends in pediatric nephrotic syndrome.

Hiroshi Tamura
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引用次数: 8

Abstract

Nephrotic syndrome (NS) is relatively common in children, with most of its histological types being minimal changed disease. Its etiology has long been attributed to lymphocyte (especially T-cell) dysfunction, while T-cell-mediated vascular hyperpermeability increases protein permeability in glomerular capillaries, leading to proteinuria and hypoproteinemia. Based on this etiology, steroids and immunosuppressive drugs that are effective against this disease have also been considered to correct T-cell dysfunction. However, in recent years, this has been questioned. The primary cause of NS has been considered damage to glomerular epithelial cells and podocyte-related proteins. Therefore, we first describe the changes in expression of molecules involved in NS etiology, and then describe the mechanism by which abnormal expression of these molecules induces proteinuria. Finally, we consider the mechanism by which infection causes the recurrence of NS.

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儿童肾病综合征的发展趋势。
肾病综合征(NS)在儿童中相对常见,其大多数组织学类型是最小改变的疾病。其病因一直被认为是淋巴细胞(尤其是t细胞)功能障碍,而t细胞介导的血管高通透性增加了肾小球毛细血管的蛋白质通透性,导致蛋白尿和低蛋白血症。基于这种病因,类固醇和免疫抑制药物对这种疾病有效,也被认为可以纠正t细胞功能障碍。然而,近年来,这种说法受到了质疑。NS的主要原因被认为是肾小球上皮细胞和足细胞相关蛋白的损伤。因此,我们首先描述了与NS病因相关的分子表达变化,然后描述了这些分子异常表达诱导蛋白尿的机制。最后,我们考虑感染引起NS复发的机制。
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