S100 Calcium-Binding Protein B and Glial Fibrillary Acidic Protein in Patients with Mild Traumatic Brain Injury.

Bulletin of emergency and trauma Pub Date : 2021-10-01 DOI:10.30476/BEAT.2021.89355.1231

Ali Meshkini, Amir Ghorbani Haghjo, Zahra Hasanpour Segherlou, Masoud Nouri-Vaskeh

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引用次数: 3

Abstract

Objective: To examine the GFAP and S100B ability in prevention unnecessary brain Computed tomography (CT) scan in mild traumatic brain injury (mTBI) and compare them with the single extremity fracture in orthopedic patients.

Methods: In this prospective cohort study, two orthopedics patients' groups and mTBI patients were studied to assess the biomarkers' ability in prevention unnecessary brain CT scan at the emergency setting. There were 40 orthopedics' patients with single extremity fracture and 41 mTBI patients. Brain CT scans were done for all mTBI patients.

Results: Brain CT scans showed no intracranial traumatic lesions. The median levels for S100B in the mTBI group was 14.8 (4.4-335.9) ng/L, and in orthopedic patients' group was 13.3 (5-353.10) ng/L. Statistically significant differences were observed between both groups in S100B levels (p=0.006). The median Glial Fibrillary Acidic Protein (GFAP) levels in the mTBI patients' group were 600 (400-16300) and in the orthopedic patients' groups was 60 ng/L (300-14900). Statistically significant differences were observed between groups in GFAP (p=0.041).

Conclusion: Our results showed that S100B and GFAP serum levels were significantly higher in patients with mTBI than in patients with a single limb fracture.

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S100钙结合蛋白B和胶质纤维酸性蛋白在轻度颅脑损伤中的作用。

目的:探讨GFAP和S100B在轻度外伤性脑损伤(mTBI)中预防不必要脑CT扫描的能力，并与骨科患者单肢骨折进行比较。方法:在这项前瞻性队列研究中，研究了两个骨科患者组和mTBI患者，以评估生物标志物在急诊环境中预防不必要的脑部CT扫描的能力。骨科单肢骨折40例，mTBI 41例。对所有mTBI患者进行脑部CT扫描。结果:颅脑CT扫描未见颅内外伤性病变。mTBI组S100B的中位水平为14.8 (4.4-335.9)ng/L，骨科组为13.3 (5-353.10)ng/L。两组间S100B水平差异有统计学意义(p=0.006)。mTBI患者组中位胶质纤维酸性蛋白(GFAP)水平为600(400-16300)，骨科患者组为60 ng/L(300-14900)。GFAP组间差异有统计学意义(p=0.041)。结论:我们的研究结果显示，mTBI患者血清S100B和GFAP水平明显高于单侧肢体骨折患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of emergency and trauma

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审稿时长

12 weeks

期刊介绍： BEAT: Bulletin of Emergency And Trauma is an international, peer-reviewed, quarterly journal coping with original research contributing to the field of emergency medicine and trauma. BEAT is the official journal of the Trauma Research Center (TRC) of Shiraz University of Medical Sciences (SUMS), Hungarian Trauma Society (HTS) and Lusitanian Association for Trauma and Emergency Surgery (ALTEC/LATES) aiming to be a publication of international repute that serves as a medium for dissemination and exchange of scientific knowledge in the emergency medicine and trauma. The aim of BEAT is to publish original research focusing on practicing and training of emergency medicine and trauma to publish peer-reviewed articles of current international interest in the form of original articles, brief communications, reviews, case reports, clinical images, and letters.