Sun Exposure and Vitamin D.

Current problems in dermatology Pub Date : 2021-01-01 Epub Date: 2021-10-25 DOI:10.1159/000517640
Peter Knuschke
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引用次数: 5

Abstract

Vitamin D is generally accepted in its importance on the regulation of calcium homeostasis and bone metabolism. Moreover, further health effects due to vitamin D are under discussion. In its effect, vitamin D is more like a hormone. In the classic view, a vitamin is an essential nutrient, which cannot be synthesized independently in the body. Besides nutrition, vitamin D will be produced in the body itself. The skin contains the provitamin D3 7-dehydrocholesterol, a precursor of vitamin D. Provitamin D3 will be photoconverted to previtamin D3 by UVB radiation that penetrates the skin superficially. In this way, the vitamin D metabolism will be started independent of the nutrition. In everyday life, this photosynthesis will be carried out due to the solar UVB radiation penetrating the uncovered skin. In the same spectral waveband range of UVB radiation, which causes the beneficial health effect of starting the vitamin D metabolism, the UVB radiation causes simultaneously acute and chronic harmful health effects as UV erythema (sunburn), skin aging and skin cancer. There is no vitamin D production in the skin without simultaneous DNA damage in the skin. Against this background, risks and benefits have to be balanced carefully.

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晒太阳和维生素D。
维生素D在调节钙稳态和骨代谢方面的重要性被普遍接受。此外,维生素D对健康的进一步影响正在讨论中。就其效果而言,维生素D更像是一种激素。经典观点认为,维生素是人体必需的营养物质,不能在体内独立合成。除了营养,维生素D会在体内产生。皮肤含有维生素D3原7-脱氢胆固醇,维生素d的前体。维生素D3原会被穿透皮肤表面的中波紫外线光转化为维生素D3原。这样,维生素D的代谢就会独立于营养而开始。在日常生活中,由于太阳UVB辐射穿透裸露的皮肤,这种光合作用就会进行。在UVB辐射的同一光谱波段范围内,UVB辐射引起启动维生素D代谢的有益健康效果,同时引起急性和慢性有害健康影响,如紫外线红斑(晒伤),皮肤老化和皮肤癌。在皮肤中产生维生素D的同时,皮肤中的DNA也会受到损伤。在这种背景下,风险和利益必须谨慎平衡。
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