Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma.

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL International Journal of Molecular and Cellular Medicine Pub Date : 2021-01-01 Epub Date: 2021-09-01 DOI:10.22088/IJMCM.BUMS.10.2.123

Kruti Mehta, Kinjal Patel, Shashank Pandya, Prabhudas Patel

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Abstract

Aberrant protein glycosylation is known to be associated with the development of various cancers. Although fucosylation is essential for normal biological functions, alterations in fucosylation are strongly implicated in cancer and increasing metastatic potential. Altered fucosyltarnsferases (FUTs) and fucosidases are found to be involved in many types of malignancies. In this study, we examined the mRNA expressions of fucosidase (FUCA1) and FUTs (FUTs (FUT3, FUT4, FUT5, FUT6, FUT8) in human oral cancer tissues. All FUTs and FUCA1 were significantly (P ≤0.05) down-regulated in malignant tissues in comparison with their adjacent normal tissues. The relationship between the clinicopathological parameters and the expression of FUTs and FUCA1 revealed that higher mRNA levels of FUT4, FUT5, and FUT8 and lower levels of FUT3 were associated with progression of disease and lymph node metastasis in oral carcinoma indicating their role in oral cancer progression. Collectively, results suggest that elevated mRNA levels of FUT4, FUT5 and FUT8 may be used as worst prognostic indicators for oral carcinoma.

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聚焦酰基转移酶和聚焦酶mRNA表达改变预测人类口腔癌预后。

已知异常蛋白糖基化与各种癌症的发生有关。虽然聚焦化对正常的生物学功能至关重要，但聚焦化的改变与癌症和增加转移潜力密切相关。在许多类型的恶性肿瘤中发现了聚焦蛋白转化酶和聚焦酶的改变。在本研究中，我们检测了聚焦酶(FUCA1)和FUTs (FUTs (FUT3、FUT4、FUT5、FUT6、FUT8)在人类口腔癌组织中的mRNA表达。与癌旁正常组织相比，肿瘤组织中FUTs和FUCA1均显著(P≤0.05)下调。临床病理参数与FUTs和FUCA1表达的关系显示，FUT4、FUT5和FUT8 mRNA水平升高和FUT3 mRNA水平降低与口腔癌的疾病进展和淋巴结转移相关，提示其在口腔癌进展中的作用。总的来说，结果表明FUT4、FUT5和FUT8 mRNA水平升高可能被用作口腔癌的最差预后指标。

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International Journal of Molecular and Cellular Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

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3.60

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0.00%

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期刊介绍： The International Journal of Molecular and Cellular Medicine (IJMCM) is a peer-reviewed, quarterly publication of Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. The journal covers all cellular & molecular biology and medicine disciplines such as the genetic basis of disease, biomarker discovery in diagnosis and treatment, genomics and proteomics, bioinformatics, computer applications in human biology, stem cells and tissue engineering, medical biotechnology, nanomedicine, cellular processes related to growth, death and survival, clinical biochemistry, molecular & cellular immunology, molecular and cellular aspects of infectious disease and cancer research. IJMCM is a free access journal. All open access articles published in IJMCM are distributed under the terms of the Creative Commons Attribution CC BY. The journal doesn''t have any submission and article processing charges (APCs).