Macroautophagy and normal aging of the nervous system: Lessons from animal models.

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2021-10-06 eCollection Date: 2021-10-01 DOI:10.15698/cst2021.10.257
Emmanouela Kallergi, Vassiliki Nikoletopoulou
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引用次数: 5

Abstract

Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highly associated with a decline in brain function in humans, as well as in other animals. Macroautophagy is a fundamental arm of the proteostasis network, safeguarding proper protein turnover during different cellular states and against diverse cellular stressors. An intricate interplay between macroautophagy and aging is beginning to unravel, with the emergence of new tools, including those for monitoring autophagy in cultured neurons and in the nervous system of different organisms in vivo. Here, we review recent findings on the impact of aging on neuronal integrity and on neuronal macroautophagy, as they emerge from studies in invertebrate and mammalian models.

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巨噬和神经系统的正常衰老:来自动物模型的教训。
衰老代表了细胞应激的一种累积形式,这被认为挑战了蛋白质平衡的许多方面。不分裂的、长寿命的神经元特别容易受到压力的影响,毫不奇怪,即使是正常的衰老也与人类和其他动物的大脑功能下降密切相关。巨噬是蛋白质平衡网络的一个基本环节,在不同的细胞状态和不同的细胞应激源下保护适当的蛋白质周转。随着新工具的出现,巨噬与衰老之间错综复杂的相互作用开始被解开,包括监测培养神经元和体内不同生物神经系统中自噬的工具。在这里,我们回顾了最近在无脊椎动物和哺乳动物模型研究中发现的衰老对神经元完整性和神经元巨噬的影响。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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