No Evidence for Constitutive Innate Immune Senescence in a Longitudinal Study of a Wild Bird.

IF 1.8 3区 生物学 Q3 PHYSIOLOGY Physiological and Biochemical Zoology Pub Date : 2022-01-01 DOI:10.1086/717937
Michael J Roast, Nataly Hidalgo Aranzamendi, Niki Teunissen, Marie Fan, Simon Verhulst, Anne Peters
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引用次数: 3

Abstract

AbstractAging is associated with declines in physiological performance; declining immune defenses particularly could have consequences for age-related fitness and survival. In aging vertebrates, adaptive (memory-based) immune responses typically become impaired, innate (nonspecific) responses undergo lesser declines, and inflammation increases. Longitudinal studies of immune functions in wild animals are rare, yet they are needed to understand immunosenescence under evolutionarily relevant conditions. Using longitudinal data from a tropical passerine (Malurus coronatus) population, we investigate how population trends emerge from within-individual changes and between-individual heterogeneity (e.g., selective disappearance) in immune status. We quantified constitutive immune indexes (haptoglobin [inflammation associated], natural antibodies, complement [lytic] activity, and heterophil-lymphocyte ratio; n=505-631) in individuals sampled one to seven times over 5 yr. Unexpectedly, longitudinal analyses showed no age-related change within individuals in any immune index, despite sufficient power to detect within-individual change. Between individuals, we found age-related declines in natural antibodies and increases in heterophil-lymphocyte ratios. However, selective disappearance could not adequately explain between-individual age effects, and longitudinal models could not explain our data better than cross-sectional analyses. The lack of clear within-individual immunosenescence is itself notable. Persistent levels of haptoglobin, complement activity, and natural antibodies into old age suggests that these immune components are maintained, potentially with adaptive significance.

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在一项对野鸟的纵向研究中,没有证据表明构成性先天免疫衰老。
摘要衰老与生理机能下降有关;免疫防御能力的下降尤其可能对与年龄相关的健康和生存产生影响。在衰老的脊椎动物中,适应性(基于记忆的)免疫反应通常会受损,先天(非特异性)免疫反应衰退较小,炎症增加。对野生动物免疫功能的纵向研究很少,但这对于了解进化相关条件下的免疫衰老是必要的。利用热带雀形鱼(Malurus coronatus)种群的纵向数据,我们研究了免疫状态下个体内变化和个体间异质性(如选择性消失)如何产生种群趋势。我们量化了组成免疫指标(触珠蛋白[炎症相关]、天然抗体、补体[溶解]活性和嗜异性淋巴细胞比率);n=505-631),在5年内采样1至7次。出乎意料的是,纵向分析显示,尽管有足够的能力检测个体内的变化,但个体内的任何免疫指数都没有与年龄相关的变化。在个体之间,我们发现天然抗体与年龄相关的下降和嗜异性淋巴细胞比率的增加。然而,选择性消失不能充分解释个体之间的年龄效应,纵向模型也不能比横断面分析更好地解释我们的数据。缺乏明确的个体免疫衰老本身是值得注意的。接触珠蛋白、补体活性和天然抗体的持续水平表明,这些免疫成分得以维持,可能具有适应性意义。
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来源期刊
CiteScore
3.20
自引率
6.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Physiological and Biochemical Zoology: Ecological and Evolutionary Approaches primarily publishes original research in animal physiology and biochemistry as considered from behavioral, ecological, and/or evolutionary perspectives. Studies at all levels of biological organization from the molecular to the whole organism are welcome, and work that integrates across levels of organization is particularly encouraged. Studies that focus on behavior or morphology are welcome, so long as they include ties to physiology or biochemistry, in addition to having an ecological or evolutionary context. Subdisciplines of interest include nutrition and digestion, salt and water balance, epithelial and membrane transport, gas exchange and transport, acid-base balance, temperature adaptation, energetics, structure and function of macromolecules, chemical coordination and signal transduction, nitrogen metabolism and excretion, locomotion and muscle function, biomechanics, circulation, behavioral, comparative and mechanistic endocrinology, sensory physiology, neural coordination, and ecotoxicology ecoimmunology.
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