Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke.

IF 3 4区医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI:10.1155/2022/4106131

Xuemei Quan, Su Hu, Chaoguo Meng, Lulu Cheng, Yujie Lu, Yumei Xia, Wenmei Li, Huo Liang, Mengting Li, Zhijian Liang

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引用次数: 7

Abstract

Objective: The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS).

Methods: In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p < 0.01 and cluster p < 0.05) correction was applied. The correlation analyses were performed between clinical scores and altered metrics values.

Results: Compared to HCs, patients with acute BGIS showed decreased ALFF in the right supramarginal gyrus (SMG) in the conventional and slow-4 bands, increased fALFF in the right middle frontal gyrus (MFG) in the conventional and slow-4 bands, and increased fALFF in the bilateral caudate in the slow-5 frequency band. The fALFF value of the right caudate in the slow-5 frequency band was negatively correlated with the clinical scores.

Conclusion: In conclusion, this study showed the alterations in ALFF and fALFF in three frequency bands between patients with acute BGIS and HCs. The results reflected that the abnormal LFO amplitude might be related with different frequency bands and promoted our understanding of pathophysiological mechanism in acute BGIS.

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急性基底节区缺血性脑卒中患者低频波动幅度的频率特异性变化。

目的:探讨急性基底节区缺血性脑卒中(BGIS)患者自发性脑活动的不同频带特征。方法:2019年5月至2020年12月，对34例急性BGIS患者和44例健康对照者进行静息状态功能磁共振成像(rs-fMRI)检查。两种振幅方法，包括低频波动幅度(ALFF)和分数ALFF (fALFF)在三个频段(常规频段:0.01-0.08 Hz;慢-5频段:0.01-0.027 Hz;慢-4频段:0.027 ~ 0.073 Hz)评价急性BGIS患者和健康对照(hc)的自发性脑活动。采用高斯随机场理论(GRF，体素p < 0.01，聚类p < 0.05)校正。临床评分与改变后的指标值之间进行相关性分析。结果:与hc相比，急性BGIS患者在常规和慢4波段表现为右侧边缘上回(SMG)的ALFF降低，在常规和慢4波段表现为右侧额叶中回(MFG)的fALFF升高，在慢5波段表现为双侧尾状核的fALFF升高。慢-5频段右尾状核的fALFF值与临床评分呈负相关。结论:本研究显示急性BGIS和hcc患者ALFF和fALFF三个频带的变化。结果表明，LFO异常振幅可能与不同频段有关，有助于我们对急性BGIS的病理生理机制的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity NEUROSCIENCES-

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.