Preclinical Evidence for the Mechanisms of Transcranial Direct Current Stimulation in the Treatment of Psychiatric Disorders; A Systematic Review.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2023-11-01 Epub Date: 2021-12-13 DOI:10.1177/15500594211066151
Yuji Yamada, Tomiki Sumiyoshi
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引用次数: 5

Abstract

Backgrounds. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique for the treatment of several psychiatric disorders, eg, mood disorders and schizophrenia. Although tDCS provides a promising approach, its neurobiological mechanisms remain to be explored. Objectives. To provide a systematic review of animal studies, and consider how tDCS ameliorates psychiatric conditions. Methods. A literature search was conducted on English articles identified by PubMed. We defined the inclusion criteria as follows: (1) articles published from the original data; (2) experimental studies in animals; (3) studies delivering direct current transcranially, ie, positioning electrodes onto the skull. Results. 138 papers met the inclusion criteria. 62 papers deal with model animals without any dysfunctions, followed by 52 papers for neurological disorder models, and 12 for psychiatric disorder models. The most studied category of functional areas is neurocognition, followed by motor functions and pain. These studies overall suggest the role for the late long-term potentiation (LTP) via anodal stimulation in the therapeutic effects of tDCS. Conclusions. tDCS Anodal stimulation may provide a novel therapeutic strategy to particularly enhance neurocognition in psychiatric disorders. Its mechanisms are likely to involve facilitation of the late LTP.

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经颅直流电刺激治疗精神疾病机制的临床前证据;系统回顾。
背景。经颅直流电刺激(tDCS)是一种非侵入性脑刺激技术,用于治疗几种精神疾病,如情绪障碍和精神分裂症。尽管tDCS提供了一种有前景的方法,但其神经生物学机制仍有待探索。目标。提供动物研究的系统综述,并考虑tDCS如何改善精神状况。方法。对PubMed鉴定的英文文章进行了文献检索。我们将纳入标准定义为:(1)根据原始数据发表的文章;(2) 动物实验研究;(3) 经颅输送直流电的研究(将电极定位在颅骨上)。后果138篇论文符合入选标准。62篇论文涉及没有任何功能障碍的模型动物,其次是52篇关于神经障碍模型的论文,12篇关于精神障碍模型的文章。研究最多的功能领域是神经认知,其次是运动功能和疼痛。这些研究总体上表明了通过阳极刺激的晚期长时程增强(LTP)在tDCS治疗效果中的作用。结论。tDCS肛门刺激可能提供一种新的治疗策略,特别是增强精神疾病的神经认知。其机制可能涉及促进晚期LTP。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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