Prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Nepal.

IF 1.3 Q4 RESPIRATORY SYSTEM Public Health Action Pub Date : 2021-11-01 DOI:10.5588/pha.21.0042

P Pradhan, P Rajbhandari, S B Nagaraja, P Shrestha, R Grigoryan, S Satyanarayana, H Davtyan

{"title":"Prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Nepal.","authors":"P Pradhan, P Rajbhandari, S B Nagaraja, P Shrestha, R Grigoryan, S Satyanarayana, H Davtyan","doi":"10.5588/pha.21.0042","DOIUrl":null,"url":null,"abstract":"Setting: Patan Hospital, Lalitpur, Nepal.Objectives: To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S. aureus infection between January 2018 and December 2020.Design: This was a cross-sectional study using electronic and paper-based hospital records of patients with S. aureus infection.Results: Of the 1,804 patients with S. aureus infection, 1,027 patients (57%, 95% CI 55-59) had MRSA. The MRSA were susceptible to vancomycin (100%), linezolid (96%), doxycycline (96%), chloramphenicol (86%) and cotrimoxazole (70%), and resistant to erythromycin (68%), clindamycin (56%), gentamycin (58%), ciprofloxacin (92%) and ofloxacin (91%). The prevalence of MRSA was higher in 2019, among out-patients, and in respiratory samples, and lower in blood samples. Of the 142 in-patients with MRSA, 93% had a successful clinical outcome (cured/improved).Conclusion: More than 50% of patients with S. aureus infection had MRSA that were resistant to commonly available antibiotics. This calls for strengthening surveil-lance and good infection control practices in this hospital.","PeriodicalId":46239,"journal":{"name":"Public Health Action","volume":"11 Suppl 1","pages":"46-51"},"PeriodicalIF":1.3000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575383/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health Action","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5588/pha.21.0042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 3

Abstract

Setting: Patan Hospital, Lalitpur, Nepal.

Objectives: To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S. aureus infection between January 2018 and December 2020.

Design: This was a cross-sectional study using electronic and paper-based hospital records of patients with S. aureus infection.

Results: Of the 1,804 patients with S. aureus infection, 1,027 patients (57%, 95% CI 55-59) had MRSA. The MRSA were susceptible to vancomycin (100%), linezolid (96%), doxycycline (96%), chloramphenicol (86%) and cotrimoxazole (70%), and resistant to erythromycin (68%), clindamycin (56%), gentamycin (58%), ciprofloxacin (92%) and ofloxacin (91%). The prevalence of MRSA was higher in 2019, among out-patients, and in respiratory samples, and lower in blood samples. Of the 142 in-patients with MRSA, 93% had a successful clinical outcome (cured/improved).

Conclusion: More than 50% of patients with S. aureus infection had MRSA that were resistant to commonly available antibiotics. This calls for strengthening surveil-lance and good infection control practices in this hospital.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

尼泊尔一家三级医院耐甲氧西林金黄色葡萄球菌的流行情况。

地点:尼泊尔拉利特普尔帕坦医院。目的:了解1)耐甲氧西林金黄色葡萄球菌(MRSA)的流行情况及其抗生素敏感性;2)与MRSA感染相关的人口学和临床特征;3) 2018年1月至2020年12月金黄色葡萄球菌感染患者中MRSA感染住院患者的治疗结果。设计:这是一项横断面研究，使用了金黄色葡萄球菌感染患者的电子和纸质医院记录。结果:1804例金黄色葡萄球菌感染患者中，1027例(57%，95% CI 55-59)有MRSA。MRSA对万古霉素(100%)、利奈唑胺(96%)、多西环素(96%)、氯霉素(86%)、复方新诺明(70%)敏感，对红霉素(68%)、克林霉素(56%)、庆大霉素(58%)、环丙沙星(92%)、氧氟沙星(91%)耐药。2019年，MRSA在门诊患者和呼吸道样本中的患病率较高，而血液样本中的患病率较低。在142例MRSA住院患者中，93%有成功的临床结果(治愈/改善)。结论:50%以上的金黄色葡萄球菌感染患者存在对常用抗生素耐药的MRSA。这就要求在该医院加强监测和良好的感染控制措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Public Health Action RESPIRATORY SYSTEM-

自引率

0.00%

发文量

期刊介绍： Launched on 1 May 2011, Public Health Action (PHA) is an official publication of the International Union Against Tuberculosis and Lung Disease (The Union). It is an open access, online journal available world-wide to physicians, health workers, researchers, professors, students and decision-makers, including public health centres, medical, university and pharmaceutical libraries, hospitals, clinics, foundations and institutions. PHA is a peer-reviewed scholarly journal that actively encourages, communicates and reports new knowledge, dialogue and controversy in health systems and services for people in vulnerable and resource-limited communities — all topics that reflect the mission of The Union, Health solutions for the poor.