Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.
Filippo Migliorini, Jörg Eschweiler, Christian Götze, Arne Driessen, Markus Tingart, Nicola Maffulli
{"title":"Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.","authors":"Filippo Migliorini, Jörg Eschweiler, Christian Götze, Arne Driessen, Markus Tingart, Nicola Maffulli","doi":"10.1093/bmb/ldac004","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Chondral defects of the knee are common and their treatment is challenging.</p><p><strong>Source of data: </strong>PubMed, Google scholar, Embase and Scopus databases.</p><p><strong>Areas of agreement: </strong>Both autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee.</p><p><strong>Areas of controversy: </strong>It is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial.</p><p><strong>Growing points: </strong>To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.</p><p><strong>Areas timely for developing research: </strong>AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.</p>","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"141 1","pages":"47-59"},"PeriodicalIF":6.7000,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351375/pdf/","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British medical bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/bmb/ldac004","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 6
Abstract
Introduction: Chondral defects of the knee are common and their treatment is challenging.
Source of data: PubMed, Google scholar, Embase and Scopus databases.
Areas of agreement: Both autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee.
Areas of controversy: It is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial.
Growing points: To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.
Areas timely for developing research: AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.
膝关节软骨缺损是常见的，其治疗具有挑战性。数据来源:PubMed, Google scholar, Embase和Scopus数据库。一致领域:自体基质诱导的软骨形成(AMIC)和膜诱导的自体软骨细胞植入(mACI)已被用于膝关节软骨缺损的治疗。争议领域:在中期随访中，对于膝关节软骨缺损的治疗，AMIC和mACI是否提供了相同的结果，这是有争议的。尽管有大量的临床研究，但最佳治疗方法仍存在争议。生长点:探讨中期随访时AMIC是否优于mACI。及时开展研究的领域:对于膝关节软骨缺损，AMIC可能比mACI提供更好的结果。需要进一步的研究在临床环境中验证这些结果。
期刊介绍：
British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries.
Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
