Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin.

IF 5.5 3区 材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2022-04-01 DOI:10.1249/JES.0000000000000278
Ana P Pinto, Eduardo R Ropelle, Joe Quadrilatero, Adelino S R da Silva
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引用次数: 2

Abstract

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.

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体育锻炼与肝脏自噬:IL-6和Irisin的潜在作用。
自噬失调导致肝脏疾病。尽管一些研究已经检验了耐力和阻力运动对自噬激活的影响,但导致骨骼肌-肝脏串扰的潜在肌因子仍然未知。基于实验研究和生物信息学,我们假设白细胞介素6(IL-6)和鸢尾素可能是收缩诱导的调节肝脏自噬反应的分子释放的关键参与者。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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