Is It Stevens-Johnson Syndrome or MIS-C with Mucocutaneous Involvement?

IF 0.7 Q4 PEDIATRICS Case Reports in Pediatrics Pub Date : 2021-12-24 eCollection Date: 2021-01-01 DOI:10.1155/2021/1812545

Abdollah Karimi, Elham Pourbakhtiaran, Mazdak Fallahi, Fereshteh Karbasian, Shahnaz Armin, Delara Babaie

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Abstract

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) can be present in the form of multisystem inflammatory disease in children. Case Presentation. A 25-month-old boy presented with fever, malaise, diffuse maculopapular rashes, and mucosal involvement during the COVID-19 pandemic. He was first diagnosed with Stevens-Johnson syndrome (SJS). Further evaluation revealed lymphopenia, thrombocytopenia, and elevated levels of C-reactive protein (CRP), ferritin, and fibrinogen. This was followed by a positive polymerase chain reaction (PCR) test for COVID-19. In addition to receiving initial care for SJS, he was treated for MIS-C, which led to his recovery after four days.

Conclusion: COVID-19 infection should be considered in children with fever and dermatological features during the pandemic because it may cause different features of the multisystem inflammatory syndrome in children (MIS-C), suggestive of delayed hyperimmune response.

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是史蒂文斯-约翰逊综合征还是皮肤黏膜受累的 MIS-C？

背景：严重急性呼吸系统综合征冠状病毒-2（SARS-COV-2）可表现为儿童多系统炎症性疾病。病例介绍。一名 25 个月大的男孩在 COVID-19 大流行期间出现发热、乏力、弥漫性斑丘疹和粘膜受累。他首先被诊断为史蒂文斯-约翰逊综合征（SJS）。进一步检查发现，他患有淋巴细胞减少症、血小板减少症，C反应蛋白（CRP）、铁蛋白和纤维蛋白原水平升高。随后，COVID-19聚合酶链反应（PCR）检测呈阳性。除了接受 SJS 初步治疗外，他还接受了 MIS-C 治疗，四天后康复：结论：在流感大流行期间，发烧并伴有皮肤病特征的儿童应考虑感染 COVID-19，因为它可能导致儿童多系统炎症综合征（MIS-C）的不同特征，提示延迟性超免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Pediatrics PEDIATRICS-

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11.10%

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审稿时长

13 weeks