Acute myelogenous leukemia - current recommendations and approaches in molecular-genetic assessment.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-06-14 Print Date: 2022-06-01 DOI:10.2478/rjim-2022-0004
Dinnar Yahya, Mari Hachmeriyan, Ilina Micheva, Trifon Chervenkov
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引用次数: 1

Abstract

Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors. Overall assessment of patients with the disease requires among everything else, a comprehensive investigation of the genetic basis through various methods such as cytogenetic and molecular-genetic ones. This clarification provides diagnostic refinement and carries prognostic and predictive value in respect of essential therapeutic choices.With this review of the literature, we focus on summarizing the latest recommendations and preferred genetic methods, as well as on emphasizing on their general benefits and limitations. Since none of these methods is actually totipotent, we also aim to shed light over the often-difficult choice of appropriate genetic analyses.

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急性髓性白血病-分子遗传学评估的当前建议和方法。
急性髓性白血病是一种多步骤的血液系统恶性肿瘤,影响骨髓前体细胞的功能、生长、增殖和细胞周期。对患者进行全面评估,首先需要通过细胞遗传学和分子遗传学等多种方法对遗传基础进行全面调查。这种澄清提供了诊断的精细化,并在基本治疗选择方面具有预后和预测价值。通过对文献的回顾,我们重点总结了最新的推荐和首选的遗传方法,并强调了它们的一般优点和局限性。由于这些方法中没有一种是全能的,我们还旨在阐明通常很难选择适当的基因分析。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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