MACULAR SENSITIVITY AND CAPILLARY PERFUSION IN HIGHLY MYOPIC EYES WITH MYOPIC MACULAR DEGENERATION.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2022-03-01 DOI:10.1097/IAE.0000000000003333
Feihui Zheng, Jacqueline Chua, Yin Ci Sim, Bingyao Tan, Marco Yu, Qiu Ying Wong, Yee Shan Dan, Rachel S Chong, Chui Ming Gemmy Cheung, Marcus Ang, Shu Yen Lee, Tien Yin Wong, Leopold Schmetterer, Chee Wai Wong, Quan V Hoang
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引用次数: 4

Abstract

Purpose: To evaluate the interrelationship between macular sensitivity and retinal perfusion density (PD) in eyes with myopic macular degeneration (MMD).

Methods: One hundred and thirty-eight highly myopic eyes from 82 adult participants were recruited. Macular sensitivity was evaluated using the Microperimeter MP-3. Retinal PD was measured using the PLEX Elite 9000 swept source optical coherence tomography angiography. Macular sensitivity values between different categories of MMD and its relationship with optical coherence tomography angiography measurements were evaluated using multivariable linear mixed models, adjusting for age and axial length.

Results: Macular sensitivity reduced with increasing severity of MMD (β ≤ -0.95, P < 0.001), whereas the best-corrected visual acuity was not associated with MMD severity (P > 0.04). Persons who were older (β = -0.08, P < 0.001), with longer axial length (β = -0.32, P = 0.005), presence of macular diffuse choroidal atrophy (β = -2.16, P < 0.001) or worse MMD (β = -5.70, P < 0.001), and presence of macular posterior staphyloma (β ≤ -2.98, P < 0.001) or Fuchs spot (β = -1.58, P = 0.04) were associated with reduced macular sensitivity. Macular sensitivity was significantly associated with deep retinal PD in MMD (β = 0.15, P = 0.004) but not with superficial retinal PD (P = 0.62).

Conclusion: There was a strong correlation between reduced macular sensitivity and increasing MMD severity, even in mild MMD independent of the best-corrected visual acuity. Furthermore, macular sensitivity was correlated with deep retinal PD, suggesting a vasculature-function relationship in MMD.

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高度近视伴近视性黄斑变性的黄斑敏感性和毛细血管灌注。
目的:探讨近视性黄斑变性(MMD)患者黄斑敏感性与视网膜灌注密度(PD)的关系。方法:选取82名成人高度近视眼138只。使用Microperimeter MP-3评估黄斑敏感性。使用PLEX Elite 9000扫描源光学相干断层扫描血管造影测量视网膜PD。使用多变量线性混合模型评估不同类别烟雾病的黄斑敏感性值及其与光学相干断层扫描血管造影测量的关系,调整年龄和轴向长度。结果:黄斑敏感度随烟雾病严重程度的增加而降低(β≤-0.95,P < 0.001),而最佳矫正视力与烟雾病严重程度无关(P > 0.04)。年龄较大(β = -0.08, P < 0.001)、轴长较长(β = -0.32, P = 0.005)、黄斑弥漫性脉络膜萎缩(β = -2.16, P < 0.001)或较严重的烟雾病(β = -5.70, P < 0.001)、黄斑后葡萄肿(β≤-2.98,P < 0.001)或Fuchs斑(β = -1.58, P = 0.04)与黄斑敏感性降低相关。黄斑敏感性与烟雾病患者深部视网膜PD显著相关(β = 0.15, P = 0.004),但与浅表视网膜PD无关(P = 0.62)。结论:黄斑敏感性降低与烟雾病严重程度增加之间存在很强的相关性,即使是独立于最佳矫正视力的轻度烟雾病。此外,黄斑敏感性与深视网膜PD相关,提示烟雾病的血管功能关系。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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